The Trail Making Test in prodromal Huntington disease: Contributions of disease progression to test performance

Justin J. F O'Rourke; Leigh J Beglinger; Megan M Smith; James Mills; David J Moser; Kelly C Rowe; Douglas R Langbehn; Kevin Duff; Julie C Stout; Deborah L Harrington; Noelle Carlozzi; Jane S Paulsen; PREDICT-HD Investigators of the Huntington Study Group

doi:10.1080/13803395.2010.541228

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The Trail Making Test in prodromal Huntington disease: Contributions of disease progression to test performance

Journal article

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Peer reviewed

The Trail Making Test in prodromal Huntington disease: Contributions of disease progression to test performance

Justin J. F O'Rourke, Leigh J Beglinger, Megan M Smith, James Mills, David J Moser, Kelly C Rowe, Douglas R Langbehn, Kevin Duff, Julie C Stout, Deborah L Harrington, …

Journal of clinical and experimental neuropsychology, Vol.33(5), pp.567-579

06/01/2011

DOI: 10.1080/13803395.2010.541228

PMCID: PMC3159183

PMID: 21302170

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https://admin.research-repository.uwa.edu.au/en/publications/fa7a054e-0291-4bf9-ad1d-e0a7f16b7d15View

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Abstract

We examined the Trail Making Test (TMT) in a sample of 767 participants with prodromal Huntington disease (prodromal HD) and 217 healthy comparisons to determine the contributions of motor, psychiatric, and cognitive changes to TMT scores. Eight traditional and derived TMT scores were also evaluated for their ability to differentiate prodromal participants closer to estimated age of diagnosis from those farther away and prodromal individuals from healthy comparisons. Results indicate that motor signs only mildly affected Part A, and psychiatric symptoms did not affect either part. Tests of perceptual processing, visual scanning, and attention were primarily associated with Part A, and executive functioning (response inhibition, set-shifting), processing speed, and working memory were associated with Part B. Additionally, TMT scores differentiated between healthy comparisons and prodromal HD individuals as far as 9-15 years before estimated diagnosis. In participants manifesting prodromal motor signs and psychiatric symptoms, the TMT primarily measures cognition and is able to discriminate between groups based on health status and estimated time to diagnosis.

Cognition

Motor

Neurodegenerative

Huntington disease

Psychiatric

Details

Title: Subtitle: The Trail Making Test in prodromal Huntington disease: Contributions of disease progression to test performance
Creators: Justin J. F O'Rourke - Department of Counseling Psychology , The University of Iowa
Leigh J Beglinger - Department of Psychiatry , The University of Iowa
Megan M Smith - Department of Psychiatry , The University of Iowa
James Mills - Department of Psychiatry , The University of Iowa
David J Moser - Department of Psychiatry , The University of Iowa
Kelly C Rowe - Department of Neuroscience , The University of Iowa
Douglas R Langbehn - Department of Psychiatry , The University of Iowa
Kevin Duff - Department of Psychiatry , The University of Iowa
Julie C Stout - School of Psychology, Psychiatry, and Psychological Medicine, Monash University
Deborah L Harrington - Department of Radiology , University of California San Diego
Noelle Carlozzi - Kessler Foundation Research Center
Jane S Paulsen - Department of Neurology , The University of Iowa
PREDICT-HD Investigators of the Huntington Study Group
Resource Type: Journal article
Publication Details: Journal of clinical and experimental neuropsychology, Vol.33(5), pp.567-579
DOI: 10.1080/13803395.2010.541228
PMID: 21302170
PMCID: PMC3159183
NLM abbreviation: J Clin Exp Neuropsychol
ISSN: 1380-3395
eISSN: 1744-411X
Publisher: Taylor & Francis Group
Language: English
Date published: 06/01/2011
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Medicine Administration
Record Identifier: 9984003428802771

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