Journal article
The Translational Research Program in Cancer Differences across Populations
Cancer epidemiology, biomarkers & prevention, Vol.34(9), pp.1472-1482
09/02/2025
DOI: 10.1158/1055-9965.EPI-24-1711
PMCID: PMC12349377
PMID: 40576634
Abstract
Colorectal cancer (CRC) incidence and mortality vary substantially across populations. The Translational Research Program in Cancer Differences across Populations (TRPCDP) was established in 2020 to address differences in CRC incidence and mortality rates within the United States.
TRPCDP centralized data acquisition and harmonization across three sites in the U.S. to create a well-annotated resource of CRC tumors across four populations: African American/Black, Alaska Native, Hispanic/Latino/a, and non-Hispanic White. Using a case-control framework, patients with lethal CRC were matched to two controls with non-lethal CRC. Formalin-fixed paraffin-embedded tumor and normal tissue were retrieved and sent for centralized pathology review, followed by DNA and RNA extraction and tissue microarray development. Multi-omics and spatial profiling are underway to evaluate the transcriptome, proteome, and microbiome. Patient demographic and clinical data were obtained by medical record review, patient self-report, or linkage to cancer registries. Additional health-related factors were assessed using geospatial linkage.
The virtual biorepository includes 7,181 patients [African American (n=1,345), Alaska Native (n=1,640), Hispanic (n=1,659), and non-Hispanic White (n=2,537)]. Tissue blocks (1,594 tumor, 728 normal colon) were selected for 938 patients. To date, DNA and RNA have been extracted (n=831) and tissue microarrays have been constructed (n=414). Transcriptomic, spatial tumor profiling (multiplex immunofluorescence, PhenoCycler, GeoMx) and microbiome data (16S rRNAseq, ddPCR) are available.
The TRPCDP has developed a clinically annotated biorepository for future molecular epidemiology studies.
TRPCDP is a unique program that supports collaborative research, community engagement, and pipeline development for the next generation of scientists.
Details
- Title: Subtitle
- The Translational Research Program in Cancer Differences across Populations
- Creators
- Jane C Figueiredo - Cedars-Sinai Medical CenterDiana Redwood - Alaska Native Tribal Health ConsortiumLi Li - Ochsner Health SystemElizabeth Donato - Fred Hutch Cancer CenterDaniel Fort - Ochsner Health SystemEric E Fox - Advisory Board CompanyWilliam M Grady - Fred Hutch Cancer CenterHeather Green - Ochsner Health SystemTabitha A Harrison - University of WashingtonCarl Haupt - Ochsner Health SystemLi Hsu - Fred Hutch Cancer CenterMeredith A J Hullar - Fred Hutch Cancer CenterJeroen R Huyghe - Fred Hutch Cancer CenterWenora Johnson - Patient-Centered Outcomes Research InstituteAmanda L Koehne - Fred Hutch Cancer CenterScott D LaBrie - Cancer ConsortiumMeredith A Lakey - Ochsner Health SystemMingGang Lin - Fred Hutch Cancer CenterNicole C Loroña - Cedars-Sinai Medical CenterGrace A Maresh - Ochsner Health SystemMarc Matrana - Ochsner Health SystemJonathan D Mizrahi - Ochsner Health SystemSarah H Nash - University of IowaNathalie T Nguyen - Cedars-Sinai Medical CenterJennifer L Paruch - Ochsner Health SystemAmanda I Phipps - Fred Hutch Cancer CenterConghui Qu - Fred Hutch Cancer CenterTimothy W Randolph - Fred Hutch Cancer CenterStephanie Romo - Cedars-Sinai Medical CenterClaire E Thomas - Fred Hutch Cancer CenterSushma Thomas - Fred Hutch Cancer CenterJames Tiesinga - Alaska Native Medical CenterCharles Whitlow - Ochsner Health SystemCecilia C S Yeung - Fred Hutch Cancer CenterHang Yin - University of WashingtonCraig M Zibilich - Ochsner Health SystemChristopher I Li - Fred Hutch Cancer CenterTimothy K Thomas - Alaska Native Tribal Health ConsortiumUlrike Peters - Fred Hutch Cancer Center
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.34(9), pp.1472-1482
- DOI
- 10.1158/1055-9965.EPI-24-1711
- PMID
- 40576634
- PMCID
- PMC12349377
- NLM abbreviation
- Cancer Epidemiol Biomarkers Prev
- ISSN
- 1538-7755
- eISSN
- 1538-7755
- Publisher
- American Association for Cancer Research; PHILADELPHIA
- Grant note
- National Cancer Institute (NCI)Alaska Native Tribal Health ConsortiumSouthcentral FoundationThe findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the NIH: P20CA252733, P50CA285275, R01CA280639, R01CA155101, R01CA238087, R01CA284732, R01CA248931, U01CA290673 NIH NCIGoldman Sachs Foundation: U. Peters: SCR_022612 V Foundation: U. Peters: SCR_022606, P30 CA015704 Genomics and Bioinformatics Shared ResourceV Foundation
We acknowledge the research participants of projects conducted by the TRPCDP, the contributions and support of the Alaska Native Tribal Health Consortium and the Southcentral Foundation Board of Directors for review and approval of this manuscript, and the staff of the TRPCDP-participating institutions for their work on the study. The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the NIH. This research was supported by several funding sources, including the NIH NCI grant P20CA252733: J.C. Figueiredo, D. Redwood, L. Li, E. Donato, W.M. Grady, H. Green, T.A. Harrison, L. Hsu, M.A.J. Hullar, J.R. Huyghe, A.L. Koehne, M. Lin, G.A. Maresh, N.T. Nguyen, A.I. Phipps, C. Qu, T.W. Randolph, S. Romo, C.E. Thomas, S. Thomas, U. Peters, C.I. Li, and T.K. Thomas; grant P50CA285275: D Redwood, L. Li, E. Donato, W.M. Grady, H. Green, T.A. Harrison, L. Hsu, M.A.J. Hullar, J.R. Huyghe, A.L. Koehne, M. Lin, G.A. Maresh, M. Matrana, J.D. Mizrahi, N.T. Nguyen, A.I. Phipps, C. Qu, T.W. Randolph, S. Romo, C.E. Thomas, S. Thomas, C.C.S. Yeung, U. Peters, C.I. Li, T.K. Thomas, and J.C. Figueiredo; grant R01CA280639: U. Peters, D. Redwood, E. Donato, L. Hsu, A.L. Koehne, M. Lin, C. Qu, S. Thomas, and J.R. Huyghe; grants R01CA155101, R01CA238087, R01CA284732, and R01CA248931: J.C. Figueiredo; grant U01CA290673: D. Redwood, U. Peters, and C.I. Li; Goldman Sachs Foundation: U. Peters, M.A.J. Hullar, L. Hsu, M. Lin, G.A. Maresh, C. Qu, T.K. Thomas, L. Li, D. Redwood, S. Thomas, C.E. Thomas, J.R. Huyghe, and C.I. Li; and V Foundation: U. Peters, L. Hsu, M. Lin, C. Qu, J.R. Huyghe, T.K. Thomas, S. Thomas, D. Redwood, C.E. Thomas, and C.I. Li. This research also benefited from the support of shared resources: Experimental Histopathology Shared Resource (RRID: SCR_022612); Genomics and Bioinformatics Shared Resource (RRID: SCR_022606); and Biospecimen Processing and Biorepository Shared Resource: part of the Fred Hutchinson Cancer Center/University of Washington/Seattle Children's Cancer Consortium (P30 CA015704). Furthermore, the V Foundation contributed to the support of this research.
- Language
- English
- Electronic publication date
- 06/27/2025
- Date published
- 09/02/2025
- Academic Unit
- Epidemiology; Center for Social Science Innovation; Community and Behavioral Health
- Record Identifier
- 9984833629102771
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