Journal article
The Use of PC12 Cells for the Study of the Mechanism of Action of Neurotrophic Factors: Signal Transduction and Programmed Cell Death
Methods (San Diego, Calif.), Vol.7(3), pp.222-237
1995
DOI: 10.1006/meth.1995.1028
Abstract
The PC12 cell line is one of the most widely used of all neuronal cell lines. Over 2200 studies using PC12 cells have been published since the first in 1974. It is so widely used because it possesses properties that make it applicable to a wide variety of neurobiological problems. This article is a brief overview of some neurobiological issues that have been approached in recent years using the PC12 cell line and the properties of PC12 cells that have allowed their application to these problems. The intent is to provide an idea of the versatility of this line and of the types of studies that have successfully employed it. This may suggest potential approaches to solving problems in the readers own research. A major focus of this article is on the use of PC12 cells as a model for the study of neurotrophic factor signal transduction. PC12 cells have proved to be a particularly valuable model for this purpose and a significant fraction of studies using PC12 cells, particularly recent studies, have been directed toward this end.
Details
- Title: Subtitle
- The Use of PC12 Cells for the Study of the Mechanism of Action of Neurotrophic Factors: Signal Transduction and Programmed Cell Death
- Creators
- S.H Green - Department of Biological Sciences, University of Iowa, 138 Biology Building, Iowa City, Iowa 52242-1324
- Resource Type
- Journal article
- Publication Details
- Methods (San Diego, Calif.), Vol.7(3), pp.222-237
- Publisher
- Elsevier Inc
- DOI
- 10.1006/meth.1995.1028
- ISSN
- 1046-2023
- eISSN
- 1095-9130
- Language
- English
- Date published
- 1995
- Academic Unit
- Biology; Otolaryngology
- Record Identifier
- 9984217526602771
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