Journal article
The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States
Clinical infectious diseases, Vol.61(4), pp.496-502
08/15/2015
DOI: 10.1093/cid/civ334
PMCID: PMC4542597
PMID: 25904375
Abstract
Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.
Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma.
Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.
Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
Details
- Title: Subtitle
- The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States
- Creators
- Colleen S. Kraft - Emory UniversityAngela L. Hewlett - Univ Nebraska Med Ctr, Div Infect Dis, Dept Internal Med, Omaha, NE USAScott Koepsell - Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USAAnne M. Winkler - Emory UniversityChristopher J. Kratochvil - Univ Nebraska Med Ctr, Off Vice Chancellor Res, Omaha, NE USALuAnn Larson - Univ Nebraska Med Ctr, Ctr Clin & Translat Res, Omaha, NE USAJay B. Varkey - Emory UniversityAneesh K. Mehta - Emory UniversityMarshall Lyon - Emory UniversityRachel J. Friedman-Moraco - Emory UniversityVincent C. Marconi - Emory UniversityCharles E. Hill - Emory UniversityJames N. Sullivan - University of Nebraska Medical CenterDaniel W. Johnson - University of Nebraska Medical CenterSteven J. Lisco - University of Nebraska Medical CenterMark J. Mulligan - Emory UniversityTimothy M. Uyeki - Centers for Disease Control and PreventionAnita K. McElroy - Centers for Disease Control and PreventionTara Sealy - Centers for Disease Control and PreventionShelley Campbell - Centers for Disease Control and PreventionChristina Spiropoulou - Centers for Disease Control and PreventionUte Stroeher - Ctr Dis Control & Prevent, Atlanta, GA USAIan Crozier - World Health Organization - PakistanRichard Sacra - University of Massachusetts Chan Medical SchoolMichael J. Connor - Emory UniversityViranuj Sueblinvong - Emory UniversityHarold A. Franch - Emory UniversityPhilip W. Smith - Univ Nebraska Med Ctr, Div Infect Dis, Dept Internal Med, Omaha, NE USABruce S. Ribner - Emory UniversityEmory Serious Communicable Diseases Unit
- Contributors
- Jim Blum (Contributor) - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.61(4), pp.496-502
- DOI
- 10.1093/cid/civ334
- PMID
- 25904375
- PMCID
- PMC4542597
- NLM abbreviation
- Clin Infect Dis
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Grant note
- K12HD072245 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UL1TR000454 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) K08AA021404 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) UL1TR000454 / National Center for Advancing Translational Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Date published
- 08/15/2015
- Academic Unit
- Anesthesia
- Record Identifier
- 9984296143902771
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