Journal article
The Value of Patient Registries to Advance Basic and Translational Research in the Area of Traumatic Brain Injury
Frontiers in behavioral neuroscience, Vol.16, p.846919
04/25/2022
DOI: 10.3389/fnbeh.2022.846919
PMCID: PMC9082794
PMID: 35548696
Abstract
The number of individuals affected by traumatic brain injury (TBI) is growing globally. TBIs may cause a range of physical, cognitive, and psychiatric deficits that can negatively impact employment, academic attainment, community independence, and interpersonal relationships. Although there has been a significant decrease in the number of injury related deaths over the past several decades, there has been no corresponding reduction in injury related disability over the same time period. We propose that patient registries with large, representative samples and rich multidimensional and longitudinal data have tremendous value in advancing basic and translational research and in capturing, characterizing, and predicting individual differences in deficit profile and outcomes. Patient registries, together with recent theoretical and methodological advances in analytic approaches and neuroscience, provide powerful tools for brain injury research and for leveraging the heterogeneity that has traditionally been cited as a barrier inhibiting progress in treatment research and clinical practice. We report on our experiences, and challenges, in developing and maintaining our own patient registry. We conclude by pointing to some future opportunities for discovery that are afforded by a registry model.
Details
- Title: Subtitle
- The Value of Patient Registries to Advance Basic and Translational Research in the Area of Traumatic Brain Injury
- Creators
- Melissa C. Duff - Meharry Medical CollegeEmily L. Morrow - Vanderbilt University Medical CenterMalcolm Edwards - Meharry Medical CollegeRyan McCurdy - Vanderbilt University Medical CenterSharice Clough - Vanderbilt University Medical CenterNirav Patel - Vanderbilt University Medical CenterKimberly Walsh - Vanderbilt University Medical CenterNatalie V. Covington - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Frontiers in behavioral neuroscience, Vol.16, p.846919
- DOI
- 10.3389/fnbeh.2022.846919
- PMID
- 35548696
- PMCID
- PMC9082794
- NLM abbreviation
- Front Behav Neurosci
- ISSN
- 1662-5153
- eISSN
- 1662-5153
- Publisher
- Frontiers Media S.A; LAUSANNE
- Grant note
- ;
- Language
- English
- Date published
- 04/25/2022
- Academic Unit
- Communication Sciences and Disorders
- Record Identifier
- 9985113182202771
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