Journal article
The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase
Nature (London), Vol.349(6311), pp.717-719
1991
DOI: 10.1038/349717a0
PMID: 1996140
Abstract
The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of maternal mRNA gives cells derived from different regions of the egg distinctive capacities for protein synthesis. We show here that An3 mRNA encodes a protein with 74% identity to a protein encoded by the testes-specific mRNA PL10 found in mouse, which is proposed to have RNA helicase activity. Because the gene encoding An3 mRNA is reactivated after gastrulation and remains active throughout embryogenesis, we have examined its distribution in embryonic and adult tissues. Unlike PL10 mRNA, which is primarily restricted to the testes, An3 mRNA is broadly distributed in later development.
Details
- Title: Subtitle
- The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase
- Creators
- R GURURAJAN - Univ. Iowa, dep. biochemistry, Iowa City IA 52242, United StatesH PERRY-O'KEEFE - Univ. Iowa, dep. biochemistry, Iowa City IA 52242, United StatesD. A MELTON - Univ. Iowa, dep. biochemistry, Iowa City IA 52242, United StatesD. L WEEKS - Univ. Iowa, dep. biochemistry, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Nature (London), Vol.349(6311), pp.717-719
- Publisher
- Nature Publishing; London
- DOI
- 10.1038/349717a0
- PMID
- 1996140
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- Language
- English
- Date published
- 1991
- Academic Unit
- Stead Family Department of Pediatrics; Biochemistry and Molecular Biology
- Record Identifier
- 9984025259602771
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