The Zebrafish as a Model Host for Invasive Fungal Infections

Emily E Rosowski; Benjamin P Knox; Linda S Archambault; Anna Huttenlocher; Nancy P Keller; Robert T Wheeler; J Muse Davis

doi:10.3390/jof4040136

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The Zebrafish as a Model Host for Invasive Fungal Infections

Journal article

Open access

Peer reviewed

The Zebrafish as a Model Host for Invasive Fungal Infections

Emily E Rosowski, Benjamin P Knox, Linda S Archambault, Anna Huttenlocher, Nancy P Keller, Robert T Wheeler and J Muse Davis

Journal of fungi (Basel), Vol.4(4), p.136

12/13/2018

DOI: 10.3390/jof4040136

PMCID: PMC6308935

PMID: 30551557

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Abstract

The zebrafish has become a widely accepted model host for studies of infectious disease, including fungal infections. The species is genetically tractable, and the larvae are transparent and amenable to prolonged in vivo imaging and small molecule screening. The aim of this review is to provide a thorough introduction into the published studies of fungal infection in the zebrafish and the specific ways in which this model has benefited the field. In doing so, we hope to provide potential new zebrafish researchers with a snapshot of the current toolbox and prior results, while illustrating how the model has been used well and where the unfulfilled potential of this model can be found.

Macrophage

Aspergillus

host–pathogen interactions

innate immunity

Candida

Cryptococcus

zebrafish

mucormycosis

neutrophil

Talaromyces

Details

Title: Subtitle: The Zebrafish as a Model Host for Invasive Fungal Infections
Creators: Emily E Rosowski - Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53716, USA. erosowski@wisc.edu
Benjamin P Knox - Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53716, USA. bpknox@wisc.edu
Linda S Archambault - Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA. linda.archambault@maine.edu
Anna Huttenlocher - Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA. huttenlocher@wisc.edu
Nancy P Keller - Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA. npkeller@wisc.edu
Robert T Wheeler - Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA. robert.wheeler1@maine.edu
J Muse Davis - Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. james-davis@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of fungi (Basel), Vol.4(4), p.136
DOI: 10.3390/jof4040136
PMID: 30551557
PMCID: PMC6308935
NLM abbreviation: J Fungi (Basel)
ISSN: 2309-608X
eISSN: 2309-608X
Grant note: PATH / Burroughs Wellcome Fund R15AI133415 / National Institutes of Health 5R01AI065728-10 / National Institutes of Health K08AI132720 / National Institutes of Health ME-021821 / U.S. Department of Agriculture
Language: English
Date published: 12/13/2018
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093226702771

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