Journal article
The Zinc-Dependent Major Histocompatibility Complex Class II Binding Site of Streptococcal Pyrogenic Exotoxin C Is Critical for Maximal Superantigen Function and Toxic Activity
Infection and immunity, Vol.71(3), pp.1548-1550
03/2003
DOI: 10.1128/IAI.71.3.1548-1550.2003
PMCID: PMC148863
PMID: 12595474
Abstract
The cocrystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) revealed a zinc-dependent interaction site through residues 167, 201, and 203 on SPE C and residue 81 on the β-chain of HLA-DR2a (DRA*0101,DRB5*0101). Mutation of these SPE C residues resulted in dramatically reduced biological activities. Thus, the zinc-dependent major histocompatibility complex II binding site is critical for maximal biological function of SPE C.
Details
- Title: Subtitle
- The Zinc-Dependent Major Histocompatibility Complex Class II Binding Site of Streptococcal Pyrogenic Exotoxin C Is Critical for Maximal Superantigen Function and Toxic Activity
- Creators
- Timothy J Tripp - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455John K McCormick - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455Jennifer M Webb - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455Patrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.71(3), pp.1548-1550
- DOI
- 10.1128/IAI.71.3.1548-1550.2003
- PMID
- 12595474
- PMCID
- PMC148863
- NLM abbreviation
- Infect Immun
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Publisher
- American Society for Microbiology
- Language
- English
- Date published
- 03/2003
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001155102771
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