Journal article
The accuracy of detailed analysis of optical coherence tomography in detection of plaque lipid content: dual-imaging study with optical coherence tomography and near-infrared spectroscopy
Acta cardiologica, Vol.79(2), pp.206-214
2024
DOI: 10.1080/00015385.2024.2324214
PMID: 38465606
Abstract
Lipid-rich plaque covered by a thin fibrous cap (FC) has been identified as a frequent morphological substrate for the development of acute coronary syndrome. Optical coherence tomography (OCT) permits the identification and measurement of the FC. Near-infrared spectroscopy (NIRS) has been approved for detection of coronary lipids.
We aimed to assess the ability of detailed OCT analysis to identify coronary lipids, using NIRS as the reference method.
In total, 40 patients with acute coronary syndrome underwent imaging of a non-culprit lesion by both NIRS and OCT. For each segment, the NIRS-derived 4 mm segment with maximal lipid core burden index (maxLCBI
) was assessed. OCT analysis was performed using a semi-automated method including measurement of the fibrous cap thickness (FCT) of all detected fibroatheromas. Subsequent quantitative volumetric evaluation furnished FCT, FC surface area (FC SA), lipid arc, and FC (fibrous cap) volume data. OCT features of lipid plaques were compared with maxLCBI
. Predictors of maxLCBI
>400 was assessed by using univariable and multivariable analysis.
OCT features (mean FCT, total FC SA, FC volume, maximal, mean, and total lipid arcs) strongly correlated with the maxLCBI
(
= 0.012 for the mean FCT, respectively
< 0.001 for all other aforementioned features). The strongest predictors of maxLCBI
>400 were the maximal (
= 0.002) and mean (
= 0.002) lipid arc, and total FC SA (
= 0.012).
We found a strong correlation between the OCT-derived features and NIRS findings. Detailed OCT analysis may be reliably used for detection of the presence of coronary lipids.
Details
- Title: Subtitle
- The accuracy of detailed analysis of optical coherence tomography in detection of plaque lipid content: dual-imaging study with optical coherence tomography and near-infrared spectroscopy
- Creators
- Karel Kopriva - General University Hospital in PragueZhi Chen - University of IowaMartin Mates - Na Homolce HospitalFrantisek Holy - Na Homolce HospitalBarbora Stekla - General University Hospital in PragueMichaela Vesela - General University Hospital in PragueJan Pudil - General University Hospital in PragueMartin Chval - Charles UniversityAndreas Wahle - University of IowaMilan Sonka - University of IowaTomas Kovarnik - General University Hospital in Prague
- Resource Type
- Journal article
- Publication Details
- Acta cardiologica, Vol.79(2), pp.206-214
- DOI
- 10.1080/00015385.2024.2324214
- PMID
- 38465606
- NLM abbreviation
- Acta Cardiol
- eISSN
- 1784-973X
- Language
- English
- Electronic publication date
- 03/11/2024
- Date published
- 2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984572335802771
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