Journal article
The aging heart: exploring the role of Klotho in cardiac health/function
The Journal of Cardiovascular Aging, Vol.4(4), 24
12/20/2024
DOI: 10.20517/jca.2024.16
PMCID: PMC12341567
PMID: 40799848
Abstract
This review discusses the pathophysiological changes associated with cardiac aging and the potential therapeutic role of the anti-aging protein Klotho. It highlights key contributors to heart failure, such as arterial stiffening, myocardial fibrosis, and impaired cardiac relaxation, all of which lead to the declining function of the aging heart. This review also explores the regulation of Klotho expression, its various forms, and its impact on cardiac health, emphasizing its protective roles against oxidative stress, inflammation, and cardiac remodeling. Klotho's potential as a therapeutic target for mitigating cardiac aging and improving cardiovascular health in the elderly is a central theme, making it a promising candidate for future interventions aimed at enhancing cardiac function and longevity.
Details
- Title: Subtitle
- The aging heart: exploring the role of Klotho in cardiac health/function
- Creators
- Nastaran DaneshgarDao-Fu DaiChad E. Grueter
- Resource Type
- Journal article
- Publication Details
- The Journal of Cardiovascular Aging, Vol.4(4), 24
- DOI
- 10.20517/jca.2024.16
- PMID
- 40799848
- PMCID
- PMC12341567
- NLM abbreviation
- J Cardiovasc Aging
- ISSN
- 2768-5993
- eISSN
- 2768-5993
- Publisher
- OAE PUBLISHING INC
- Grant note
- National Institutes of Health, National Heart, Lung, and Blood Institute: R01-HL168044
Financial support and sponsorship Grueter CE was supported by the National Institutes of Health, National Heart, Lung, and Blood Institute (R01-HL168044) .
- Language
- English
- Date published
- 12/20/2024
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Craniofacial Anomalies Research Center; Internal Medicine
- Record Identifier
- 9984770785402771
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