Journal article
The amnesiac Gene Product Is Expressed in Two Neurons in the Drosophila Brain that Are Critical for Memory
Cell (Cambridge), Vol.103(5), pp.805-813
2000
DOI: 10.1016/S0092-8674(00)00183-5
PMID: 11114336
Abstract
Mutations in the
amnesiac gene in
Drosophila affect both memory retention and ethanol sensitivity. The predicted
amnesiac gene product, AMN, is an apparent preproneuropeptide, and previous studies suggest that it stimulates cAMP synthesis. Here we show that, unlike other learning-related
Drosophila proteins, AMN is not preferentially expressed in mushroom bodies. Instead, it is strongly expressed in two large neurons that project over all the lobes of the mushroom bodies, a finding that suggests a modulatory role for AMN in memory formation. Genetically engineered blockade of vesicle recycling in these cells abbreviates memory as in the
amnesiac mutant. Moreover, restoration of
amn gene expression to these cells reestablishes normal olfactory memory in an
amn deletion background. These results indicate that AMN neuropeptide release onto the mushroom bodies is critical for normal olfactory memory.
Details
- Title: Subtitle
- The amnesiac Gene Product Is Expressed in Two Neurons in the Drosophila Brain that Are Critical for Memory
- Creators
- Scott Waddell - Center for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USAJ.Douglas Armstrong - Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, United KingdomToshihiro Kitamoto - Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, USAKim Kaiser - Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, United KingdomWilliam G Quinn - Center for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
- Resource Type
- Journal article
- Publication Details
- Cell (Cambridge), Vol.103(5), pp.805-813
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0092-8674(00)00183-5
- PMID
- 11114336
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 2000
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984006454002771
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