The amniote paratympanic organ develops from a previously undiscovered sensory placode

Paul O'Neill; Siu-Shan Mak; Bernd Fritzsch; Raj K Ladher; Clare V H Baker

doi:10.1038/ncomms2036

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The amniote paratympanic organ develops from a previously undiscovered sensory placode

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The amniote paratympanic organ develops from a previously undiscovered sensory placode

Paul O'Neill, Siu-Shan Mak, Bernd Fritzsch, Raj K Ladher and Clare V H Baker

Nature communications, Vol.3(1), pp.1041-1041

2012

DOI: 10.1038/ncomms2036

PMCID: PMC3518548

PMID: 22948823

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Abstract

The paratympanic organ, a mechanosensory hair cell-containing pouch in the amniote middle ear, was first described 100 years ago, yet its origins remain unresolved. Homology with the anamniote spiracular organ is supported by association with homologous skeletal elements and similar central targets of afferent neurons, suggesting it might be a remnant of the water-dependent lateral line system, otherwise lost during the amniote transition to terrestrial life. However, this is incompatible with studies suggesting that it arises from the first epibranchial (geniculate) placode. Here we show that a previously undiscovered Sox2-positive placode, immediately dorsal to the geniculate placode, forms the paratympanic organ and its afferent neurons, which are molecularly and morphologically distinct from geniculate neurons. These data remove the only obstacle to accepting the homology of the paratympanic organ and spiracular organ. We hypothesize that the paratympanic organ/spiracular organ represents an ancient head ectoderm module, developmentally and evolutionarily independent of both lateral line and epibranchial placodes.

Ectoderm - embryology

Hair Cells, Auditory - cytology

Hair Cells, Auditory - metabolism

Vertebrates - genetics

Quail - embryology

Vertebrates - embryology

Phylogeny

SOXB1 Transcription Factors - metabolism

Chickens - metabolism

Ectoderm - metabolism

Sharks - embryology

Ear, Middle - metabolism

SOXB1 Transcription Factors - genetics

Sense Organs - embryology

Neurons, Afferent - cytology

Sharks - metabolism

Ear, Middle - embryology

Chick Embryo

Biological Evolution

Ectoderm - cytology

Animals

Vertebrates - classification

Ear, Middle - cytology

Quail - metabolism

Sense Organs - metabolism

Neurons, Afferent - metabolism

Vertebrates - metabolism

Details

Title: Subtitle: The amniote paratympanic organ develops from a previously undiscovered sensory placode
Creators: Paul O'Neill - Laboratory for Sensory Development, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan
Siu-Shan Mak
Bernd Fritzsch
Raj K Ladher
Clare V H Baker
Resource Type: Journal article
Publication Details: Nature communications, Vol.3(1), pp.1041-1041
DOI: 10.1038/ncomms2036
PMID: 22948823
PMCID: PMC3518548
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Publisher: England
Grant note: G18657 / Biotechnology and Biological Sciences Research Council P30 DC 010362 / NIDCD NIH HHS R01 DC005590 / NIDCD NIH HHS P30 DC010362 / NIDCD NIH HHS R01 DC 005590 / NIDCD NIH HHS
Language: English
Date published: 2012
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9984070236402771

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