The amygdala differentially regulates defensive behaviors evoked by CO 2

R J Taugher; B J Dlouhy; C J Kreple; A Ghobbeh; M M Conlon; Y Wang; J A Wemmie

doi:10.1016/j.bbr.2019.112236

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The amygdala differentially regulates defensive behaviors evoked by CO 2

Journal article

Peer reviewed

The amygdala differentially regulates defensive behaviors evoked by CO 2

R J Taugher, B J Dlouhy, C J Kreple, A Ghobbeh, M M Conlon, Y Wang and J A Wemmie

Behavioural brain research, Vol.377, p.112236

01/13/2020

DOI: 10.1016/j.bbr.2019.112236

PMCID: PMC6829583

PMID: 31536735

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Abstract

CO inhalation can provoke panic attacks in humans, and the likelihood is increased in patients with panic disorder. Identifying brain sites involved could provide important mechanistic insight into the illness. In mice, the amygdala has been suggested to promote CO responses; however, recent studies in humans with amygdala damage indicate the amygdala is not required for CO -induced fear and panic and might actually oppose these responses. To clarify the role of the amygdala, we produced lesions in mice paralleling the human lesions, and characterized behavioral responses to CO . Compared to sham controls, we found that amygdala-lesioned mice froze less to 10% CO , and unlike shams they also began to jump frenetically. At 20% CO , controls also exhibited jumping, suggesting it is a normal response to more extreme CO concentrations. The effect of amygdala lesions was specific to CO as amygdala-lesioned mice did not jump in response to a predator odor or to an auditory conditioned stimulus. In amygdala-lesioned mice, jumping evoked by 10% CO was eliminated by co-lesioning the dorsal periaqueductal gray, a structure implicated in panic and escape-related behaviors. Together, these observations suggest a dual role for the amygdala in the CO response: promoting CO -induced freezing, and opposing CO -induced jumping, which may help explain the exaggerated CO responses in humans with amygdala lesions.

Mice, Inbred C57BL

Fear - drug effects

Behavior, Animal - physiology

Carbon Dioxide - administration & dosage

Freezing Reaction, Cataleptic - drug effects

Amygdala - pathology

Animals

Freezing Reaction, Cataleptic - physiology

Behavior, Animal - drug effects

Mice

Carbon Dioxide - pharmacology

Locomotion - physiology

Amygdala - physiology

Periaqueductal Gray - pathology

Locomotion - drug effects

Details

Title: Subtitle: The amygdala differentially regulates defensive behaviors evoked by CO 2
Creators: R J Taugher - Department of Psychiatry, University of Iowa, Iowa City, IA, USA; Department of Veterans Affairs Medical Center, Iowa City, IA, USA
B J Dlouhy - Department of Neurosurgery, University of Iowa, Iowa City, IA, USA; Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
C J Kreple - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA; Medical Scientist Training Program, University of Iowa, Iowa City, IA, USA
A Ghobbeh - Department of Psychiatry, University of Iowa, Iowa City, IA, USA; Department of Veterans Affairs Medical Center, Iowa City, IA, USA
M M Conlon - Department of Psychiatry, University of Iowa, Iowa City, IA, USA; Department of Veterans Affairs Medical Center, Iowa City, IA, USA
Y Wang - Department of Psychiatry, University of Iowa, Iowa City, IA, USA
J A Wemmie - Department of Psychiatry, University of Iowa, Iowa City, IA, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA. Electronic address: john-wemmie@uiowa.edu
Resource Type: Journal article
Publication Details: Behavioural brain research, Vol.377, p.112236
DOI: 10.1016/j.bbr.2019.112236
PMID: 31536735
PMCID: PMC6829583
NLM abbreviation: Behav Brain Res
ISSN: 0166-4328
eISSN: 1872-7549
Publisher: Netherlands
Grant note: T32 NS045549 / NINDS NIH HHS R01 MH085724 / NIMH NIH HHS R01 MH113325 / NIMH NIH HHS R01 HL113863 / NHLBI NIH HHS I01 BX004440 / BLRD VA T32 MH019113 / NIMH NIH HHS
Language: English
Date published: 01/13/2020
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Mathematics; Neurosurgery
Record Identifier: 9984066136802771

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