Journal article
The anticholinergic drug scale as a measure of drug-related anticholinergic burden: Associations with serum anticholinergic activity
Journal of clinical pharmacology, Vol.46(12), pp.1481-1486
01/01/2006
DOI: 10.1177/0091270006292126
PMID: 17101747
Abstract
<p>Anticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS scores and SAA was determined using simple linear regression in subjects from a study of delirium in 201 long-term care facility residents who were not included in the pilot study. Simple and multiple linear regression models were then used to determine whether the ADS could be modified to more effectively predict SAA in all 297 subjects. In the replication analysis, ADS scores were significantly associated with SAA (R-2 =.0947, P <.0001). In the modification analysis, each model significantly predicted SAA, including ADS scores (R-2 =.0741, P <.0001). The modifications examined did not appear useful in optimizing the ADS. This study replicated findings on the association of the ADS with SAA. Future work will determine whether the ADS is clinically useful for preventing anticholinergic adverse effects.</p>
Details
- Title: Subtitle
- The anticholinergic drug scale as a measure of drug-related anticholinergic burden: Associations with serum anticholinergic activity
- Creators
- Ryan M CarnahanBrian C LundPaul J PerryBruce G PollockKennith R. Culp
- Resource Type
- Journal article
- Publication Details
- Journal of clinical pharmacology, Vol.46(12), pp.1481-1486
- DOI
- 10.1177/0091270006292126
- PMID
- 17101747
- NLM abbreviation
- J Clin Pharmacol
- ISSN
- 0091-2700
- Language
- English
- Date published
- 01/01/2006
- Academic Unit
- Nursing; Injury Prevention Research Center
- Record Identifier
- 9983557613902771
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