The antimicrobial activity of Prevention mouthrinse

D R Drake; J S Wefel; D Dunkerson; K Hogle

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The antimicrobial activity of Prevention mouthrinse

Journal article

Peer reviewed

The antimicrobial activity of Prevention mouthrinse

D R Drake, J S Wefel, D Dunkerson and K Hogle

American journal of dentistry, Vol.6(5), pp.239-242

10/1993

PMID: 7880467

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Abstract

Prevention mouthrinse was designed to serve as a vital supplement to normal oral hygiene procedures. To determine the antimicrobial potency of this mouthrinse, minimal inhibitory concentrations (MICs), bactericidal kinetics, and short-term exposure studies were conducted. A spectrum of oral microorganisms was employed in this investigation: Streptococcus sanguis, Streptococcus anginosus, Streptococcus mutans, Actinomyces viscosus, Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Eikenella corrodens, Porphyromonas gingivalis, Serratia marcescens and Candida albicans. Microorganisms were cultured in standard enriched media and under appropriate atmospheric conditions. Inhibition assays were conducted in tubes, with each mouthrinse dilution assayed in triplicate. MIC determinations revealed that all of the microorganisms studied were highly susceptible to Prevention mouthrinse, with MICs ranging from 16-fold to 128-fold dilutions. Bactericidal kinetics assays showed rapid killing of the test organisms in the presence of the mouthrinse. Brief (5-minute) exposure of S. mutans to 8-fold diluted mouthrinse resulted in a substantial delay in growth. Under the constraints of this type of study, Prevention mouthrinse exhibited potent antimicrobial activity against all of the microorganisms studied. We support the notion that Prevention mouthrinse may be a valuable supplement to normal oral hygiene procedures. A 6-month clinical trial assessing the in vivo efficacy of Prevention mouthrinse is currently being conducted.

Actinomyces viscosus - drug effects

Anti-Infective Agents - pharmacology

Hydrogen Peroxide - pharmacology

Sulfates - pharmacology

Fusobacterium nucleatum - drug effects

Serratia - drug effects

Streptococcus - drug effects

Microbial Sensitivity Tests

Eikenella corrodens - drug effects

Mouthwashes - pharmacology

Anti-Bacterial Agents

Citrates - pharmacology

Candida albicans - drug effects

Zinc Compounds - pharmacology

Aggregatibacter actinomycetemcomitans - drug effects

Bacteria, Anaerobic - drug effects

Drug Combinations

Porphyromonas gingivalis - drug effects

Details

Title: Subtitle: The antimicrobial activity of Prevention mouthrinse
Creators: D R Drake - Dows Institute for Dental Research and Center for Clinical Studies, College of Dentistry, University of Iowa 52242
J S Wefel
D Dunkerson
K Hogle
Resource Type: Journal article
Publication Details: American journal of dentistry, Vol.6(5), pp.239-242
Publisher: United States
PMID: 7880467
ISSN: 0894-8275
Language: English
Date published: 10/1993
Academic Unit: Endodontics; Dental Research
Record Identifier: 9984065981902771

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