Journal article
The antinociceptive effects of prostaglandin antagonists in the rat
European journal of pharmacology, Vol.133(3), pp.249-256
1987
DOI: 10.1016/0014-2999(87)90020-3
PMID: 2881791
Abstract
This study examined the antinociceptive effects of two prostaglandin antagonists, SC-25469 and SC-19220 in the rat. SC-25469 and SC-19220 inhibited acetic acid-induced writhing with ED
50 s of 6.9 and 6.8 mg/kg p.o., respectively. When compared to other analgesics, the rank order of potency in the writhing test was morphine > pentazocine = U-50,488 > SC-25469 = SC-19220 > ibuprofen > aspirin > acetaminophen. SC-25469 (150 and 300 mg/kg p.o.) and SC-19220 (50–300 mg/kg p.o.) also suppressed the behavioral response to s.c. injection of formalin, as did aspirin (50–150 mg/kg p.o.), ibuprofen (25–100 mg/kg p.o.) and acetaminophen (300 mg/kg p.o.). However, the suppression was not of the magnitude observed after administration of morphine (ED
50: 0.9 mg/kg s.c.), pentazocine (ED
50: 2.4 mg/kg s.c.) or U-50,488 (ED
50: 0.8 mg/kg s.c.). This study demonstrates the antinociceptive properties of prostaglandin antagonists in two distinct tests of nociception.
Details
- Title: Subtitle
- The antinociceptive effects of prostaglandin antagonists in the rat
- Creators
- Edward J Drower - Departments of Central Nervous System, G.D. Searle & Co., Research and Development Division, Skokie, IL 60077, U.S.AAwilda Stapelfeld - Departments of Central Nervous System, G.D. Searle & Co., Research and Development Division, Skokie, IL 60077, U.S.ARichard A Mueller - Departments of Immunoinflammatory Diseases Research, G.D. Searle & Co., Research and Development Division, Skokie, IL 60077, U.S.ADonna L Hammond - Departments of Central Nervous System, G.D. Searle & Co., Research and Development Division, Skokie, IL 60077, U.S.A
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.133(3), pp.249-256
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-2999(87)90020-3
- PMID
- 2881791
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 1987
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984007196802771
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