The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads

Jessica E Goetz; Douglas R Pedersen; Duane A Robinson; Michael G Conzemius; Thomas E Baer; Thomas D Brown

doi:10.1016/j.jbiomech.2008.04.032

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The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads

Journal article

Peer reviewed

The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads

Jessica E Goetz, Douglas R Pedersen, Duane A Robinson, Michael G Conzemius, Thomas E Baer and Thomas D Brown

Journal of biomechanics, Vol.41(10), pp.2197-2205

2008

DOI: 10.1016/j.jbiomech.2008.04.032

PMCID: PMC2612542

PMID: 18561937

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Abstract

Cryoinsult-induced osteonecrosis (ON) in the emu femoral head provides a unique opportunity to systematically explore the pathogenesis of ON in an animal model that progresses to human-like femoral head collapse. Among the various characteristics of cryoinsult, the maximally cold temperature attained is one plausible determinant of tissue necrosis. To identify the critical isotherm required to induce development of ON in the cancellous bone of the emu femoral head, a thermal finite element (FE) model of intraoperative cryoinsults was developed. Thermal material property values of emu cancellous bone were estimated from FE simulations of cryoinsult to emu cadaver femora, by varying model properties until the FE-generated temperatures matched corresponding thermocouple measurements. The resulting FE model, with emu bone-specific thermal properties augmented to include blood flow effects, was then used to study intraoperatively performed in vivo cryoinsults. Comparisons of minimum temperatures attained at FE nodes corresponding to the three-dimensional histologically apparent boundary of the region of ON were made for six experimental cryoinsults. Series-wide, a critical isotherm of 3.5 °C best corresponded to the boundary of the osteonecrotic lesions.

Cryoinsult

Finite element model

Osteonecrosis

Histology

Emu

Details

Title: Subtitle: The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads
Creators: Jessica E Goetz - Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242-1100, USA
Douglas R Pedersen - Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242-1100, USA
Duane A Robinson - Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, USA
Michael G Conzemius - Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, USA
Thomas E Baer - Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242-1100, USA
Thomas D Brown - Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242-1100, USA
Resource Type: Journal article
Publication Details: Journal of biomechanics, Vol.41(10), pp.2197-2205
DOI: 10.1016/j.jbiomech.2008.04.032
PMID: 18561937
PMCID: PMC2612542
NLM abbreviation: J Biomech
ISSN: 0021-9290
eISSN: 1873-2380
Publisher: Elsevier Ltd
Language: English
Date published: 2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation
Record Identifier: 9984040290102771

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