Journal article
The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans
Neurotoxicology and teratology, Vol.28(1), pp.39-48
2006
DOI: 10.1016/j.ntt.2005.10.006
PMID: 16343843
Abstract
We previously described a polymorphism in exon 4 of the gene encoding the heme biosynthetic pathway enzyme, coproporphyrinogen oxidase (CPOX4), which significantly modifies the effect of mercury exposure on urinary porphyrin excretion in humans. Here, we examined potential consequences of this polymorphism (“CPOX4”) on performance within neurobehavioral domains, symptoms, and mood that are known to be affected by elemental mercury (Hg°) exposure in human subjects. A behavioral test battery was administered on the day of urine and buccal cell collections for 194 male dentists (DDs) and 233 female dental assistants (DAs) occupationally exposed to Hg° for an average of 19 and 10 years, respectively. Subjects had no history of health disorders and were employed for a minimum of 5 years in the dental profession. Respective mean urinary mercury (HgU) levels in DDs and DAs were 3.32 (4.87) μg/l and 1.98 (2.29) μg/l. Corresponding indices of chronic occupational Hg° exposure, weighted for historical exposure, were 27.1 (20.6) and 15.2 (12.3). The frequencies of the homogygous common (A/A), heterozygous (A/C), and homozygous polymorphic (C/C) genotypes were 75%, 23% and 2% for DDs and 73%, 25%, and 2% for DAs, respectively. DDs and DAs were evaluated separately. Regression analyses controlled for age, premorbid intelligence, alcohol consumption, and education.
Statistically significant associations with HgU (
p
<
0.05) were found for nine measures among DDs (BEES Digit Span
Forward and Backward, WMS-R Visual Reproduction
N Correct, BEES Symbol Digit
Rate, BEES Finger Tapping
Dom/Non-dom,
and Alternate Partialed, Hand Steadiness
Factor1, and BEES Tracking), and eight measures among DAs (BEES Digit Span
Forward, BEES Symbol Digit
Rate, BEES Pattern Discrimination
Rate, BEES Trailmaking B, BEES Finger Tapping
Dom/Non-dom, and Alternate Partialed, Hand Steadiness
Factor1, and Vibration Sensitivity
Hits). CPOX4 status was associated with four measures in DDs (BEES Spatial Span
Forward, BEES Pattern Memory
N Correct, BEES Symbol Digit
Rate, and BEES Vigilance
Hit) and five measures in DAs (BEES Digit Span
Forward, WMS-R Visual Reproductions
N Correct, BEES Symbol Digit
Rate, BEES Simple and Choice Reaction Time
Move. Both groups experienced an additive effect (no interaction term) for HgU and the CPOX4 polymorphisms on the Digit
Rate whereas DAs also had additive effects for BEES Digit Span
Forward and for Beck's Depression factor ‘Worthlessness’. These exploratory findings suggest that the CPOX4 polymorphism may affect susceptibility for specific neurobehavioral functions associated with mercury exposure in human subjects.
Details
- Title: Subtitle
- The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans
- Creators
- Diana Echeverria - Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue North, Suite 400, Seattle, WA 98109, United StatesJames S Woods - Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue North, Suite 400, Seattle, WA 98109, United StatesNicholas J Heyer - Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue North, Suite 400, Seattle, WA 98109, United StatesDianne Rohlman - Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR, United StatesFederico M Farin - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United StatesTingting Li - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United StatesClaire E Garabedian - Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue North, Suite 400, Seattle, WA 98109, United States
- Resource Type
- Journal article
- Publication Details
- Neurotoxicology and teratology, Vol.28(1), pp.39-48
- DOI
- 10.1016/j.ntt.2005.10.006
- PMID
- 16343843
- NLM abbreviation
- Neurotoxicol Teratol
- ISSN
- 0892-0362
- eISSN
- 1872-9738
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2006
- Academic Unit
- Occupational and Environmental Health; International Programs; Injury Prevention Research Center
- Record Identifier
- 9983997463202771
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