The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study

Kathleen M Hayden; Daniel P Beavers; Susan E Steck; James R Hebert; Fred K Tabung; Nitin Shivappa; Ramon Casanova; JoAnn E Manson; Claudia B Padula; Elena Salmoirago-Blotcher; Linda G Snetselaar; Oleg Zaslavsky; Stephen R Rapp

doi:10.1016/j.jalz.2017.04.004

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The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study

Journal article

Peer reviewed

The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study

Kathleen M Hayden, Daniel P Beavers, Susan E Steck, James R Hebert, Fred K Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E Manson, Claudia B Padula, Elena Salmoirago-Blotcher, …

Alzheimer's & dementia, Vol.13(11), pp.1187-1196

11/2017

DOI: 10.1016/j.jalz.2017.04.004

PMCID: PMC5909961

PMID: 28531379

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Abstract

The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. Baseline food frequency questionnaires from n = 7085 women (aged 65–79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally. Mixed effect models evaluated cognitive decline on over time; Cox models evaluated the risk of MCI or dementia across DII groups. Over an average of 9.7 years, there were 1081 incident cases of cognitive impairment. Higher DII scores were associated with greater cognitive decline and earlier onset of cognitive impairment. Adjusted hazard ratios (HRs) comparing lower (anti-inflammatory; group 1 referent) DII scores to the higher scores were group 2-HR: 1.01 (0.86–1.20); group 3-HR: 0.99 (0.82–1.18); and group 4-HR: 1.27 (1.06–1.52). Diets with the highest pro-inflammatory potential were associated with higher risk of MCI or dementia.

Inflammation

Dementia

Cognitive decline

Survival analysis

Diet

Mild cognitive impairment

Details

Title: Subtitle: The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study
Creators: Kathleen M Hayden - Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA
Daniel P Beavers - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
Susan E Steck - Cancer Prevention and Control Program, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
James R Hebert - Cancer Prevention and Control Program, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Fred K Tabung - Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Nitin Shivappa - Cancer Prevention and Control Program, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Ramon Casanova - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
JoAnn E Manson - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Claudia B Padula - VA Palo Alto Health Care System and Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
Elena Salmoirago-Blotcher - Centers for Behavioral and Preventive Medicine, The Miriam Hospital; Departments of Medicine and Epidemiology, Warren Alpert School of Medicine and School of Public Health, Brown University, Providence, RI, USA
Linda G Snetselaar - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
Oleg Zaslavsky - Department of Behavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA
Stephen R Rapp - Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA
Resource Type: Journal article
Publication Details: Alzheimer's & dementia, Vol.13(11), pp.1187-1196
DOI: 10.1016/j.jalz.2017.04.004
PMID: 28531379
PMCID: PMC5909961
NLM abbreviation: Alzheimers Dement
ISSN: 1552-5260
eISSN: 1552-5279
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services, award: HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C; DOI: 10.13039/100000049, name: National Institute on Aging, award: HHSN26820044221C, WHIMS‐ECHO; DOI: 10.13039/100000049, name: National Institute on Aging, award: HHSN271201100004C, HHSN26820044221C, HHSN271201100004C; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: R44DK103377; DOI: 10.13039/100000054, name: National Cancer Institute, award: K99CA207736, NCT00017953, NCT01124773
Language: English
Date published: 11/2017
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995063002771

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