Journal article
The association between course of illness and subsequent morbidity in bipolar I disorder
Journal of psychiatric research, Vol.41(1), pp.80-89
2007
DOI: 10.1016/j.jpsychires.2005.12.007
PMID: 16524592
Abstract
We examined the relationship between certain bipolar I disorder clinical course variables over 5 years with outcome over the subsequent 5-year period.
Prospective observational follow-up data of 123 bipolar I subjects were analyzed. Predictive clinical variables included the frequency and direction of switches, and the quantity, polarity and length of affective periods. Outcome variables were an affective burden index (ABI) accounting for week-by-week severity and weeks hospitalized. Bivariate analyses guided the selection of predictors for multivariable analyses against the outcome variables.
Affective burden index: while the number and direction of switches, the number of polyphasic episodes, weeks in hypomania/mania/mixed state, weeks in minor/major depression, weeks in at least marked affective syndrome, and weeks in any affective syndrome all had bivariate correlation (
p
<
0.01) with the ABI, only weeks in hypomania/mania/mixed state and weeks in minor/major depression made significant contributions in the multivariable analysis (
p
<
0.01) with the ABI.
Weeks hospitalized: weeks in at least marked affective syndrome were significantly correlated with weeks hospitalized in bivariate analysis (
p
<
0.01), and maintained a contribution to weeks hospitalized in the multivariable analysis (
p
<
0.01).
The quantity and severity of weeks in symptomatic affective states are possibly greater predictors of affective burden in bipolar I patients than the quantity and direction of affective switches.
Details
- Title: Subtitle
- The association between course of illness and subsequent morbidity in bipolar I disorder
- Creators
- D.J Mysels - St. Luke’s-Roosevelt Hospital, New York, NY, United StatesJ Endicott - New York State Psychiatric Institute, Unit 123, 1051 Riverside Drive, New York, NY 10032, United StatesJ Nee - New York State Psychiatric Institute, Unit 123, 1051 Riverside Drive, New York, NY 10032, United StatesJ.D Maser - Psychiatry Service, 151A VASDHS, 3350 La Jolla Village Drive, San Diego, CA 92161, United StatesD Solomon - Department of Psychiatry, Rhode Island Hospital, JB5S, 593 Eddy Street, Providence, RI 02903, United StatesW Coryell - Psychiatry Research-MEB, University of Iowa College of Medicine, Iowa City, IA 52242-1000, United StatesA.C Leon - Department of Psychiatry, Weill Medical College of Cornell University, 140, 525 E. 68th Street, New York, NY 10021, United States
- Resource Type
- Journal article
- Publication Details
- Journal of psychiatric research, Vol.41(1), pp.80-89
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jpsychires.2005.12.007
- PMID
- 16524592
- ISSN
- 0022-3956
- eISSN
- 1879-1379
- Language
- English
- Date published
- 2007
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003431002771
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