Journal article
The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis
Neuroscience and biobehavioral reviews, Vol.168, 105952
01/2025
DOI: 10.1016/j.neubiorev.2024.105952
PMID: 39603437
Abstract
While women tend to experience more severe psychiatric and neurobehavioral symptoms following traumatic brain injury (TBI), the connection between sex and post-TBI depression remains poorly understood. To explore the potential association between sex and post-TBI depression, we conducted a systematic review and meta-analysis, including studies with participants who had no prior diagnosis of depression. Thirteen studies met the criteria for inclusion, collectively investigating a cohort of 449,471 individuals with TBI. The median age of the subjects was 49.9 years (≥7 years old). All participants were observed across a spectrum of TBI severities, encompassing mild, moderate, and severe cases. A pooled analysis of 449,471 subjects, revealed a statistically significant difference in the risk of developing post-TBI depression between male and female patients, with females at a significantly higher risk compared to males (RR = 1.4 [95% CI, 1.29-1.52], P <.0001; I2 = 90.8%, P <.0001). This significance also appeared in mild TBI/concussion cases, and in depression after a longer period (≥ 24 months) following the TBI. These findings identify TBI as a consistent risk factor for depression, regardless of its severity or type.
Details
- Title: Subtitle
- The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis
- Creators
- Mani Ratnesh S Sandhu - University of IowaAntonia Schonwald - New York Medical CollegeMatthew Boyko - Ben-Gurion University of the NegevTamara D Jafar - University of Southern CaliforniaIsaac G Freedman - Massachusetts General HospitalJohn Woeste - Mayo Clinic in FloridaAnirudh Kurup - Mayo Clinic in FloridaMelissa C Funaro - Yale UniversityAlexander Zlotnik - Ben-Gurion University of the NegevShaun E Gruenbaum - Mayo Clinic in FloridaAladine A Elsamadicy - Yale UniversityRebecca A Reynolds - University of IowaBenjamin F Gruenbaum - Mayo Clinic in Florida
- Resource Type
- Journal article
- Publication Details
- Neuroscience and biobehavioral reviews, Vol.168, 105952
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- DOI
- 10.1016/j.neubiorev.2024.105952
- PMID
- 39603437
- ISSN
- 0149-7634
- eISSN
- 1873-7528
- Grant note
- Appendix A. Supporting information
Declaration of Competing Interest The authors have no conflicts of interest to declare. Acknowledgements The authors would like to thank Vermetha Polite of the Cushing/Whitney Medical Library, Yale University for technical support. Appendix A. Supporting information
- Language
- English
- Electronic publication date
- 11/25/2024
- Date published
- 01/2025
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984751758002771
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