The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI—The MOST study

Frank W Roemer; David T Felson; Tianzhong Yang; Jingbo Niu; Michel D Crema; Martin Englund; Michael C Nevitt; Yuqing Zhang; John A Lynch; George Y El Khoury; James Torner; Cora E Lewis; Ali Guermazi

doi:10.1016/j.semarthrit.2012.10.005

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The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI—The MOST study

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The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI—The MOST study

Frank W Roemer, David T Felson, Tianzhong Yang, Jingbo Niu, Michel D Crema, Martin Englund, Michael C Nevitt, Yuqing Zhang, John A Lynch, George Y El Khoury, …

Seminars in arthritis and rheumatism, Vol.42(6), pp.573-581

06/2013

DOI: 10.1016/j.semarthrit.2012.10.005

PMCID: PMC3640766

PMID: 23270763

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https://www.ncbi.nlm.nih.gov/pmc/articles/3640766View

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Abstract

Synovitis is thought to be a secondary phenomenon in the osteoarthritis (OA) process and the menisci might be triggers of localized synovitis. The aim was to assess the cross-sectional associations of posterior horn meniscal damage with perimeniscal synovitis, and with synovitis posterior to the posterior cruciate ligament (PCL) using contrast enhanced (CE) MRI. The Multicenter Osteoarthritis (MOST) Study is a longitudinal observational study of subjects with or at risk for knee OA. Subjects are a subset of MOST who were examined with 1.5T CE MRI and had semiquantitative synovitis (scored from 0 to 2 at 11 locations) and meniscal readings (scored with WORMS from 0 to 4) available. Logistic regression was used to assess the association of posterior meniscal damage and perimeniscal synovitis in the same compartment, and between posterior meniscal damage and synovitis posterior to the PCL. Three hundred and seventy seven knees were included (mean age 61.1 years±6.9, mean BMI 29.6±4.9, 44.3% women). The odds for ipsi-compartmental perimeniscal synovitis were increased for knees with medial posterior horn meniscal damage (adjusted odds ratio [aOR] 2.5, 95% confidence intervals [95% CI] 1.3,4.8), but not for lateral damage (aOR 1.7, 95% CI 0.4,6.6). No positive associations were found for meniscal damage and presence of synovitis posterior to the PCL (aOR 0.9, 95% CI 0.6,1.5). Meniscal damage of the posterior horns is associated with ipsi-compartmental perimensical synovitis. No associations were found for posterior horn meniscal damage with synovitis posterior to the PCL, which suggests that synovitis posterior to the PCL is likely to be triggered by different pathomechanisms.

Magnetic Resonance Imaging

Osteoarthritis

Synovitis

Meniscal damage

Details

Title: Subtitle: The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI—The MOST study
Creators: Frank W Roemer - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA
David T Felson - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Tianzhong Yang - Boston University School of Medicine
Jingbo Niu - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Michel D Crema - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA
Martin Englund - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Michael C Nevitt - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA
Yuqing Zhang - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
John A Lynch - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA
George Y El Khoury - Department of Radiology at the University of Iowa, Iowa City, IA
James Torner - Department of Epidemiology at the University of Iowa, Iowa City, IA
Cora E Lewis - Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL
Ali Guermazi - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA
Resource Type: Journal article
Publication Details: Seminars in arthritis and rheumatism, Vol.42(6), pp.573-581
DOI: 10.1016/j.semarthrit.2012.10.005
PMID: 23270763
PMCID: PMC3640766
NLM abbreviation: Semin Arthritis Rheum
ISSN: 0049-0172
eISSN: 1532-866X
Publisher: Elsevier Inc
Language: English
Date published: 06/2013
Academic Unit: Radiology; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995032502771

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