Journal article
The association between mood and anxiety disorders with vascular diseases and risk factors in a nationally representative sample
Journal of psychosomatic research, Vol.70(2), pp.145-154
2011
DOI: 10.1016/j.jpsychores.2010.07.010
PMCID: PMC3052932
PMID: 21262417
Abstract
To investigate the association between mood and anxiety disorders and vascular diseases after controlling for vascular disease risk factors.
Using a nationally representative sample of adults (
N=5692) from the National Comorbidity Survey-Replication (NCS-R), participants with mood disorders were hierarchically classified as having any lifetime history of mania, hypomania, or major depression. Anxiety disorders were also assessed. The reference group consisted of those without mental disorders. Vascular disease was determined by self-reported history of heart disease, heart attack, or stroke on the NCS-R survey. Vascular risk factors included diabetes, high blood pressure, and obesity.
In multivariate logistic regression models that controlled for obesity, high blood pressure, smoking and diabetes, vascular disease was associated with bipolar disorder in women [odds ratio (OR) 2.80, 95% confidence interval (CI) 1.63–4.80], and major depressive disorder in men (OR 1.85, 95% CI 1.17–2.92). Controlling for anxiety disorders reduced the associations in both men and women, and in fact, anxiety disorders were more strongly associated with vascular diseases in men, whereas bipolar disorder continued to be an important correlate of vascular disease in women.
These findings demonstrate the importance of evaluation of sex differences, mood disorder subtype and co-occurring anxiety disorders in assessing the association between mood disorders and vascular diseases. Future research should investigate potential biologic mechanisms for these associations in order to define potential targets for intervention.
Details
- Title: Subtitle
- The association between mood and anxiety disorders with vascular diseases and risk factors in a nationally representative sample
- Creators
- Jess G Fiedorowicz - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IAJianping He - Genetic Epidemiology Research Branch, Intramural Research Program, National Institutes of Mental Health, Bethesda, MDKathleen R Merikangas - Genetic Epidemiology Research Branch, Intramural Research Program, National Institutes of Mental Health, Bethesda, MD
- Resource Type
- Journal article
- Publication Details
- Journal of psychosomatic research, Vol.70(2), pp.145-154
- DOI
- 10.1016/j.jpsychores.2010.07.010
- PMID
- 21262417
- PMCID
- PMC3052932
- NLM abbreviation
- J Psychosom Res
- ISSN
- 0022-3999
- eISSN
- 1879-1360
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2011
- Academic Unit
- Psychiatry; Epidemiology; Iowa Neuroscience Institute
- Record Identifier
- 9984065477002771
Metrics
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