The association between pregnancy and human papilloma virus prevalence

E M Smith; S R Johnson; D Jiang; S Zaleski; C F Lynch; S Brundage; R D Anderson; L P Turek

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Journal article

The association between pregnancy and human papilloma virus prevalence

E M Smith, S R Johnson, D Jiang, S Zaleski, C F Lynch, S Brundage, R D Anderson and L P Turek

Cancer detection and prevention, Vol.15(5), pp.397-402

1991

PMID: 1661203

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Abstract

This study examined the effects of pregnancy on the prevalence of HPV infection, comparing 69 pregnant and 54 nonpregnant age-frequency matched female patients. HPV prevalence was detected by DNA hybridization using the ViraPap/ViraType dot blot procedure. The prevalence of HPV among pregnant women increased with gestational age from 8.0% in the first trimester, to 16.7% in the second, and 23.1% in the third trimester. This finding suggests that HPV infection may be activated by hormonal or other effects of pregnancy and may explain why number of pregnancies is known to be associated with increased risk of cervical dysplasia and cancer. Oncogenic HPV types 16/18 and 31/33/35 were identified with almost equal frequency in the study population whereas HPV 6/11 was seen rarely. The logistic regression models indicate that there were no significant differences between HPV positive and HPV negative groups by age, income, number of sex partners, age of first intercourse, average frequency of intercourse per month, number of pregnancies, oral contraceptive duration, or pregnancy status. There were no interaction effects. A current Pap result of cervical dysplasia (OR = 8.9; 95% confidence interval: 2.1, 38.8), oral contraceptive use (OR = 0.1; 0.03, 0.6), and education (OR = 1.4; 1.1, 1.8) were significant predictors of HPV status.

Pregnancy

DNA Probes, HPV

Prevalence

Contraceptives, Oral, Hormonal

Pregnancy Complications, Infectious - epidemiology

Humans

Middle Aged

Uterine Cervical Neoplasms - epidemiology

Uterine Cervical Dysplasia - microbiology

DNA, Viral - analysis

Logistic Models

Risk

Papillomaviridae - isolation & purification

Gestational Age

Uterine Cervical Neoplasms - microbiology

Adolescent

Adult

Female

Pregnancy Complications, Infectious - microbiology

Tumor Virus Infections - epidemiology

Uterine Cervical Dysplasia - epidemiology

Virus Activation

Details

Title: Subtitle: The association between pregnancy and human papilloma virus prevalence
Creators: E M Smith - Department of Preventive Medicine, University of Iowa, College of Medicine, Iowa City
S R Johnson
D Jiang
S Zaleski
C F Lynch
S Brundage
R D Anderson
L P Turek
Resource Type: Journal article
Publication Details: Cancer detection and prevention, Vol.15(5), pp.397-402
Publisher: England
PMID: 1661203
ISSN: 0361-090X
eISSN: 1873-443X
Grant note: 1 K07 CA 1181-01A1 / NCI NIH HHS R03 CA49303-02 / NCI NIH HHS
Language: English
Date published: 1991
Academic Unit: Epidemiology; Pathology; Obstetrics and Gynecology
Record Identifier: 9983995110002771

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57 Times Cited - Web of Science