The association between walking speed from short- and standard-distance tests with the risk of all-cause mortality among adults with radiographic knee osteoarthritis: data from three large United States cohort studies

H. Master; T. Neogi; L. F. Callahan; A. E. Nelson; M. LaValley; R. J. Cleveland; Y. M. Golightly; L. M. Thoma; Y. Zhang; D. Voinier; M. B. Christiansen; J. T. Jakiela; M. Nevitt; C. E. Lewis; L. A. Frey-Law; D. K. White

doi:10.1016/j.joca.2020.08.009

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The association between walking speed from short- and standard-distance tests with the risk of all-cause mortality among adults with radiographic knee osteoarthritis: data from three large United States cohort studies

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The association between walking speed from short- and standard-distance tests with the risk of all-cause mortality among adults with radiographic knee osteoarthritis: data from three large United States cohort studies

H. Master, T. Neogi, L. F. Callahan, A. E. Nelson, M. LaValley, R. J. Cleveland, Y. M. Golightly, L. M. Thoma, Y. Zhang, D. Voinier, …

Osteoarthritis and cartilage, Vol.28(12), pp.1551-1558

12/01/2020

DOI: 10.1016/j.joca.2020.08.009

PMCID: PMC7722103

PMID: 32861851

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Abstract

Objective: Adults with radiographic knee OA (rKOA) are at increased risk of mortality and walking difficulty may modify this relation. Little is known about specific aspects of walking difficulty that increase mortality risk. We investigated the association of walking speed (objective measure of walking difficulty) with mortality and examined the threshold that best discriminated this risk in adults with rKOA. Methods: Participants with rKOA from the Johnston County Osteoarthritis Project (JoCoOA, longitudinal population-based cohort), Osteoarthritis Initiative and Multicenter Osteoarthritis Study (OAI and MOST, cohorts of individuals with or at high risk of knee OA) were included. Baseline speed was measured via 2.4-meter (m) walk test (short-distance) in JoCoOA and 20-m walk test (standard-distance) in OAI and MOST. To examine the association of walking speed with mortality risk over 9 years, hazard ratios (HR) and 95% confidence intervals (CI) were calculated from Cox regression models adjusted for potential confounders. A Maximal Likelihood Ratio Chi-square Approach was utilized to identify an optimal threshold of walking speed predictive of mortality. Results: Deaths after 9 years of follow-up occurred in 23.3% (290/1244) of JoCoOA and 5.9% (249/4215) of OAI + MOST. Walking 0.2 m/s slower during shortand standard-distance walk tests was associated with 23% (aHR [95%CI]; 1.23 [1.10, 1.39]) and 25% (1.25 [1.09, 1.43]) higher mortality risk, respectively. Walking <0.5 m/s on short-distance and <1.2 m/s standard-distance walk tests, best discriminated those with and without mortality risk. Conclusion: Slower walking speed measured via short- and standard-distance walk tests was associated with increased mortality risk in adults with rKOA. (c) 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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Rheumatology

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Title: Subtitle: The association between walking speed from short- and standard-distance tests with the risk of all-cause mortality among adults with radiographic knee osteoarthritis: data from three large United States cohort studies
Creators: H. Master - University of Delaware
T. Neogi - Boston University
L. F. Callahan - University of North Carolina at Chapel Hill
A. E. Nelson - University of North Carolina at Chapel Hill
M. LaValley - Boston University
R. J. Cleveland - University of North Carolina at Chapel Hill
Y. M. Golightly - University of North Carolina at Chapel Hill
L. M. Thoma - University of North Carolina at Chapel Hill
Y. Zhang - Massachusetts General Hospital
D. Voinier - University of Delaware
M. B. Christiansen - University of Delaware
J. T. Jakiela - University of Delaware
M. Nevitt - University of California, San Francisco
C. E. Lewis - University of Alabama at Birmingham
L. A. Frey-Law - University of Iowa
D. K. White - University of Delaware
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage, Vol.28(12), pp.1551-1558
DOI: 10.1016/j.joca.2020.08.009
PMID: 32861851
PMCID: PMC7722103
NLM abbreviation: Osteoarthritis Cartilage
ISSN: 1063-4584
eISSN: 1522-9653
Publisher: Elsevier
Number of pages: 8
Grant note: R01AR065937 / NIAMS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) N01-AR-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-22261; N01-AR-2-2262 / National Institutes of Health (NIH), a branch of the Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Unidel Foundation Pfizer, Inc.; Pfizer GlaxoSmithKline S043; S1734; S3486; S3810; U01DP003206 / Centers for Disease Control (CDC); United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA Novartis Pharmaceuticals Corporation; Novartis Foundation for the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R21-AR071079-01A1; K12HD055931-01; K23AR070913; T32-HD007490; F32AR073090; K24-AR070892; U54 GM104941; P30 AR072520-01 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA AG18820; AG18832; AG18947; AG19069 / National Institutes of Health, a branch of the Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P60AR064166 / Multidisciplinary Clinical Research Center (MCRC) of the UNC Thurston Arthritis Research Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Merck Research Laboratories; Merck & Company
Language: English
Date published: 12/01/2020
Academic Unit: Nursing; Physical Therapy and Rehabilitation Science
Record Identifier: 9984295047402771

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