Journal article
The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis
Ophthalmology (Rochester, Minn.), Vol.100(8), pp.1199-1205
08/1993
DOI: 10.1016/S0161-6420(93)31505-8
PMID: 8341502
Abstract
To establish a human leukocyte antigen (HLA) association in a homogeneous population of patients with pars planitis. A strict set of inclusion parameters was established for the diagnosis of pars planitis. Forty patients with pars planitis who met these criteria underwent HLA analysis of class I and II phenotypes. HLA-B8 was present in 15 (37.5%) of 40 patients versus 85 (19.7%) of 431 controls (relative risk, 2.44; P = 0.011). HLA-B51 was present in 9 (22.5%) of 40 patients versus 51 (11.8%) of 431 controls (relative risk, 2.16; P = 0.049). HLA-DR2 was present in 27 (67.5%) of 40 patients versus 121 (28.0%) of 431 controls (relative risk, 5.32; P < 0.0001). HLA-DR2 has been associated with multiple sclerosis (MS). Exclusion of five patients with pars planitis in whom MS subsequently developed did not change the significance of these findings. The strongest association of pars planitis with HLA-DR2 and the temporal development of MS in some patients with pars planitis further supports an association between pars planitis and MS.
Details
- Title: Subtitle
- The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis
- Creators
- Susan M Malinowski - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa CityJose S PulidoNancy E GoekenCarl Kice BrownJames C Folk
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.100(8), pp.1199-1205
- DOI
- 10.1016/S0161-6420(93)31505-8
- PMID
- 8341502
- NLM abbreviation
- Ophthalmology
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Publisher
- United States
- Language
- English
- Date published
- 08/1993
- Academic Unit
- Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980003102771
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