The association of a HOPA polymorphism with major depression and phobia

Robert Philibert; Kristin Caspers; Douglas Langbehn; Edward P Troughton; Rebecca Yucuis; Harinder K Sandhu; Remi J Cadoret

doi:10.1053/comp.2002.33489

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The association of a HOPA polymorphism with major depression and phobia

Journal article

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Peer reviewed

The association of a HOPA polymorphism with major depression and phobia

Robert Philibert, Kristin Caspers, Douglas Langbehn, Edward P Troughton, Rebecca Yucuis, Harinder K Sandhu and Remi J Cadoret

Comprehensive psychiatry, Vol.43(5), pp.404-410

09/2002

DOI: 10.1053/comp.2002.33489

PMID: 12216017

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https://doaj.org/article/4f839813275c4b81ba7b0cdfd5693b77View

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Abstract

Thyroid hormone has a prominent role in the development and homeostasis of the central nervous system (CNS). Consequently, genes participating in thyroid hormone receptor (THR)-mediated signal transduction are prime candidates for neuropsychiatric illness susceptibility factors. Previously, we have associated exonic polymorphisms in a Xq13 thyroid receptor coactivator named HOPA with a modest increase in vulnerability to a broad spectrum of neuropsychiatric illness, including depression, psychosis, and hypothyroidism. In order to test and extend these findings, we have now examined the relationship between HOPA polymorphisms and neuropsychiatric illness in a cohort of Iowa adoptees. Consistent with our prior findings, HOPA polymorphisms were associated with an increased risk for major depression. There was suggestive evidence that the increased psychiatric morbidity in these subjects could represent epistasis, e.g., an interaction between the HOPA variant and a genetic diathesis for another psychiatric condition such as biologic parent antisocial behavior. Information about biologic parent behavior and the adoptive home environment was used to determine depressive symptoms attributable to gene-environment interaction. HOPA variant subjects continued to show significant differences in depressive symptoms when controlling for gene-environment interaction. Finally, because obesity is associated with hypothyroidism and HOPA polymorphisms are associated with hypothyroidism, we analyzed weight with respect to HOPA allele status. We found that that HOPA polymorphisms were associated with increased risk for obesity (P <.001). In summary, we conclude that HOPA polymorphisms may be a moderate risk factor for increased susceptibility to a broad spectrum of neuropsychiatric illness and hypothesize that the type of illness manifested might be related to a separate genetic diathesis.

Depressive Disorder - genetics

Family - psychology

Genetic Predisposition to Disease

Humans

Middle Aged

Depressive Disorder - etiology

Phobic Disorders - etiology

Anxiety Disorders - etiology

Polymorphism, Genetic

Genetic Variation

Receptors, Thyroid Hormone - genetics

Alleles

Adult

Anxiety Disorders - genetics

Phobic Disorders - genetics

Hypothyroidism - genetics

Adoption

Details

Title: Subtitle: The association of a HOPA polymorphism with major depression and phobia
Creators: Robert Philibert - Department of Psychiatry, Neuroscience Program, The University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242-1000, USA
Kristin Caspers
Douglas Langbehn
Edward P Troughton
Rebecca Yucuis
Harinder K Sandhu
Remi J Cadoret
Resource Type: Journal article
Publication Details: Comprehensive psychiatry, Vol.43(5), pp.404-410
DOI: 10.1053/comp.2002.33489
PMID: 12216017
NLM abbreviation: Compr Psychiatry
ISSN: 0010-440X
eISSN: 1532-8384
Publisher: United States
Grant note: R01DA05821 / NIDA NIH HHS
Language: English
Date published: 09/2002
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984003910302771

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