Journal article
The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study
Journal of human hypertension, Vol.34(11), pp.787-794
11/01/2020
DOI: 10.1038/s41371-020-0303-y
PMCID: PMC7390661
PMID: 32001828
Abstract
Cardiovascular drugs impact many pathways involved in depression pathophysiology and treatment. However, their distinct impact on mood is underrecognized and the literature is conflicting. Therefore, using a very large and well-characterised sample of older adults with hypertension, we aimed to investigate the prevalence of depressive symptoms in users of different antihypertensive classes. We analysed baseline data from 14,195 older individuals with hypertension enroled in a large clinical trial. Median age was 75 years. The association of antihypertensive use by class and depression prevalence, as measured by a validated depression scale, was determined using logistic regression models. Multivariable logistic models were implemented to account for important confounding factors. Our analyses showed a positive association between depressive symptoms and the use of beta blockers (BB) (OR: 1.37; 95% CI: 1.17-1.60, p < 0.01), compared with users of other antihypertensive classes. All other classes of antihypertensives (including angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, and calcium channel blockers) were not significantly associated with depressive symptoms. In secondary analysis, this relationship was stronger for lipophilic (39%) and nonselective BB (52%) compared with hydrophilic (26%) and selective medications (31%), respectively. This study adds further evidence for a probable association between BB and depression in a large sample of older adults with hypertension and no history of cardiovascular disease or heart failure. These findings should regenerate interest and increase awareness of clinicians about the possible adverse effects of these medications in an otherwise healthy older population.
Details
- Title: Subtitle
- The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study
- Creators
- Bruno Agustini - Deakin UniversityMohammadreza Mohebbi - Deakin UniversityRobyn L. Woods - Monash UniversityJohn J. McNeil - Monash UniversityMark R. Nelson - Menzies Research InstituteRaj C. Shah - Rush University Medical CenterAnne M. Murray - Berman Center for Outcomes and Clinical ResearchMichael E. Ernst - University of IowaChristopher M. Reid - Monash UniversityAndrew Tonkin - Monash UniversityJessica E. Lockery - Monash UniversityMichael Berk - Florey Institute of Neuroscience and Mental HealthASPREE Investigator Group
- Resource Type
- Journal article
- Publication Details
- Journal of human hypertension, Vol.34(11), pp.787-794
- DOI
- 10.1038/s41371-020-0303-y
- PMID
- 32001828
- PMCID
- PMC7390661
- NLM abbreviation
- J Hum Hypertens
- ISSN
- 0950-9240
- eISSN
- 1476-5527
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- APP1059660; APP1156072 / NHMRC Senior Principal Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia APP1045862 / NHMRC Senior Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia U01AG029824 / National Cancer Institute at the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Victorian Cancer Agency (Australia) U01AG029824 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Monash University (Australia); Monash University 334047; 1127060 / National Health and Medical Research Council of Australia; National Health and Medical Research Council (NHMRC) of Australia
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297351202771
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