Journal article
The association of frontal plane alignment to MRI-defined worsening of patellofemoral osteoarthritis: the MOST study
Osteoarthritis and cartilage, Vol.27(3), pp.459-467
03/2019
DOI: 10.1016/j.joca.2018.11.004
PMCID: PMC6391198
PMID: 30500383
Abstract
To determine the sex-specific relation of frontal plane alignment (FPA) to magnetic resonance imaging (MRI)-defined features of patellofemoral osteoarthritis, and also to tibiofemoral osteoarthritis and knee pain.
The Multicenter Osteoarthritis Study is cohort study comprised of individuals with or at risk of knee osteoarthritis. We determined the sex-specific dose–response relation of baseline FPA to MRI-defined patellofemoral and tibiofemoral structural worsening, and incident knee pain, over 7 years.
In women only, greater varus alignment was associated with medial patellofemoral osteophytes (risk ratio [RR] 1.7 [95% CI 1.2, 2.6]) and valgus with lateral patellofemoral osteophytes (RR 1.9 [1.0, 3.6]). In men, greater varus increased risk for medial tibiofemoral cartilage worsening (RR 1.7 [1.1, 2.6]), and valgus for lateral tibiofemoral cartilage worsening (RR 1.8 [1.6, 2.2]). In women, findings were similar for tibiofemoral cartilage, but varus also increased risk for medial bone marrow lesions [BMLs] (RR 2.2 [1.6, 3.1]) and medial osteophytes (RR 1.8 [1.3, 2.5]), and valgus for lateral BMLs (RR 3.3 [2.2, 4.5]) and osteophytes (RR 2.0 [1.2, 3.2]). Varus increased risk of incident pain in men (RR 1.7 [1.4, 2.2]) and women (RR 1.3 [1.0, 1.6]), valgus did so in men only (RR 1.5 [1.1, 1.9]).
FPA was associated with patellofemoral osteophyte worsening in women, though overall was more strongly associated with tibiofemoral than patellofemoral osteoarthritis feature worsening. FPA in women was more consistently associated with structural worsening, yet men had higher associations with incident pain.
Details
- Title: Subtitle
- The association of frontal plane alignment to MRI-defined worsening of patellofemoral osteoarthritis: the MOST study
- Creators
- E.M Macri - Department of Physical Therapy, University of Delaware, Newark, DE, USAD.T Felson - Clinical Epidemiology Research and Training Unit, School of Medicine, Boston University, Boston, MA, USAM.L Ziegler - Biostatistics Core, College of Health Sciences, University of Delaware, Newark, DE, USAT.D.V Cooke - School of Rehabilitation Therapy, Queen's University, Kingston, ON, CanadaA Guermazi - Quantitative Imaging Center, Department of Radiology, School of Medicine, Boston University, Boston, MA, USAF.W Roemer - Quantitative Imaging Center, Department of Radiology, School of Medicine, Boston University, Boston, MA, USAT Neogi - Clinical Epidemiology Research and Training Unit, School of Medicine, Boston University, Boston, MA, USAJ Torner - Department of Epidemiology, University of Iowa, Iowa City, IA, USAC.E Lewis - Division of Preventive Medicine, University of Alabama, Birmingham, AL, USAM.C Nevitt - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USAJ.J Stefanik - Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, MA, USA
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.27(3), pp.459-467
- DOI
- 10.1016/j.joca.2018.11.004
- PMID
- 30500383
- PMCID
- PMC6391198
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: NIH, award: U01-AG18820, U01-AG18832, U01-AG18947, U01-AG19069, AR-47785; DOI: 10.13039/100000057, name: NIH/NIGMS, award: U54-GM104941; DOI: 10.13039/100000069, name: NIH/NIAMS, award: K23AR070913; DOI: 10.13039/100000002, name: NIH, award: AR070892
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995171902771
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