The association of marital status and mortality among men with early-stage prostate cancer treated with radical prostatectomy: insight into post-prostatectomy survival strategies

Saira Khan; Kenneth G Nepple; Adam S Kibel; Gurdarshan Sandhu; Dorina Kallogjeri; Seth Strope; Robert Grubb III; Kathleen Y Wolin; Siobhan Sutcliffe

doi:10.1007/s10552-019-01194-y

Back

The association of marital status and mortality among men with early-stage prostate cancer treated with radical prostatectomy: insight into post-prostatectomy survival strategies

Journal article

Open access

Peer reviewed

The association of marital status and mortality among men with early-stage prostate cancer treated with radical prostatectomy: insight into post-prostatectomy survival strategies

Saira Khan, Kenneth G Nepple, Adam S Kibel, Gurdarshan Sandhu, Dorina Kallogjeri, Seth Strope, Robert Grubb III, Kathleen Y Wolin and Siobhan Sutcliffe

Cancer causes & control, Vol.30(8), pp.871-876

08/2019

DOI: 10.1007/s10552-019-01194-y

PMCID: PMC6739072

PMID: 31214808

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/6739072View

Open Access

Abstract

The purpose of this study was to determine the association of marital status, a marker of social support, with all-cause and prostate cancer-specific mortality in a cohort of men with early-stage prostate cancer treated with radical prostatectomy. We conducted a retrospective cohort study of 3,579 men treated for localized (stage 1-2) prostate cancer with radical prostatectomy at a single institution between 1994 and 2004. Marital status (not married vs. married) and marital history (never married, divorced, widowed vs. married) at the time of prostatectomy were examined in relation to (1) all-cause mortality and (2) prostate cancer-specific mortality using Cox proportional hazards regression. Not being married (vs. married) at the time of radical prostatectomy was associated with an increased risk of all-cause mortality [Hazard Ratio (HR) 1.42; 95% Confidence Interval (CI) 1.10, 1.85]. Similarly, in analyses of marital history, never-married men were at highest risk of all-cause mortality (HR 1.77, 95% CI 1.19, 2.63). Unmarried status (vs. married) was also associated with an increased risk of prostate cancer-specific mortality (HR 1.97; 95% CI 1.01, 3.83). Unmarried men with prostate cancer were at greater risk for death after radical prostatectomy. Among married men with prostate cancer, marriage likely serves as a multi-faceted proxy for many protective factors including social support. Future studies should explore the mechanisms underlying these findings to inform the development of novel prostate cancer survival interventions for unmarried men and those with low social support.

Aged

Cohort Studies

Humans

Male

Marital Status

Middle Aged

Proportional Hazards Models

Prostatectomy

Prostatic Neoplasms - mortality

Prostatic Neoplasms - surgery

Retrospective Studies

Social Support

Details

Title: Subtitle: The association of marital status and mortality among men with early-stage prostate cancer treated with radical prostatectomy: insight into post-prostatectomy survival strategies
Creators: Saira Khan - Washington University in St. Louis
Kenneth G Nepple - University of Iowa
Adam S Kibel - Brigham and Women's Hospital
Gurdarshan Sandhu - Mercy Clinic Neurology
Dorina Kallogjeri - Washington University in St. Louis
Seth Strope - Urology of St. Louis, St. Louis, USA
Robert Grubb III - Medical University of South Carolina
Kathleen Y Wolin - HealthCare Interactive
Siobhan Sutcliffe - Washington University in St. Louis
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.30(8), pp.871-876
DOI: 10.1007/s10552-019-01194-y
PMID: 31214808
PMCID: PMC6739072
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Grant note: T32190194 / NCI NIH HHS PC170130 / U.S. Department of Defense T32 CA190194 / NCI NIH HHS T32 CA009001 / NCI NIH HHS KM1 CA156708 / NCI NIH HHS
Language: English
Date published: 08/2019
Academic Unit: Urology
Record Identifier: 9984320855102771

Metrics

9 Record Views

26 Times Cited - Web of Science