Journal article
The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
Osteoarthritis and cartilage, Vol.17(6), pp.748-753
06/2009
DOI: 10.1016/j.joca.2008.09.013
PMCID: PMC2740855
PMID: 19008123
Abstract
To assess the cross-sectional association between meniscal status and joint effusion on magnetic resonance imaging (MRI) in knees without radiographic osteoarthritis (OA).
Knees without OA (Kellgren/Lawrence grade 0) from the Framingham and MOST studies were examined by MRI. Meniscal status was assessed with a score of 0–4 in the anterior horn/body/posterior horn of the medial/lateral meniscus and effusion was assessed using a score of 0–3. The odds ratios (ORs) of joint effusion in those with meniscal damage were estimated using a logistic regression model. A subanalysis was performed for knees without MRI-detected cartilage damage.
Of 1368 knees, 296 (21.6%) showed meniscal pathology in at least one subregion. Effusion was present in 133 (44.9%) of knees with meniscal damage vs 328 (30.6%) in those without meniscal damage. The adjusted OR of effusion in a knee with meniscal damage was 1.8, 95% confidence intervals (CI) [1.4, 2.4]. The OR of effusion for the group with meniscal pathology in two compartments was 5.4, 95% CI [2.1, 14.3]. For knees without any cartilage lesions but with meniscal damage in any compartment the OR was 2.3, 95% CI [1.1, 4.5].
Knees without OA but with meniscal pathology exhibit joint effusion to a significantly higher degree than knees without meniscal damage. The association persists for knees without cartilage damage. The prevalence of effusion is further increased when present in two compartments. Concomitant occurrence of synovial activation and meniscal damage contributes to understanding the pathophysiology of early degenerative joint disease.
Details
- Title: Subtitle
- The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
- Creators
- F.W Roemer - Quantitative Imaging Center (QIC), Department of Radiology, Boston University Medical Center, Boston, MA, USAA Guermazi - Quantitative Imaging Center (QIC), Department of Radiology, Boston University Medical Center, Boston, MA, USAD.J Hunter - Department of Research, New England Baptist Hospital, Boston, MA, USAJ Niu - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USAY Zhang - Boston UniversityM Englund - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USAM.K Javaid - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USAJ.A Lynch - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USAA Mohr - Department of Radiology, Sligo General Hospital, Sligo, IrelandJ Torner - Department of Epidemiology at the University of Iowa, Iowa City, IA, USAC.E Lewis - Division of Preventive Medicine, University of Alabama, Birmingham, AL, USAM.C Nevitt - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USAD.T Felson - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.17(6), pp.748-753
- DOI
- 10.1016/j.joca.2008.09.013
- PMID
- 19008123
- PMCID
- PMC2740855
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 06/2009
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983996090502771
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