The association of physical activity and body mass index with the risk of large bowel polyps

Kristin WALLACE; John A BARON; Margaret R KARAGAS; Bernard F COLE; Tim BYERS; Michael A BEACH; Loretta H PEARSON; Carol A BURKE; William B SILVERMAN; Robert S SANDLER

doi:10.1158/1055-9965.EPI-04-0757

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The association of physical activity and body mass index with the risk of large bowel polyps

Journal article

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The association of physical activity and body mass index with the risk of large bowel polyps

Kristin WALLACE, John A BARON, Margaret R KARAGAS, Bernard F COLE, Tim BYERS, Michael A BEACH, Loretta H PEARSON, Carol A BURKE, William B SILVERMAN and Robert S SANDLER

Cancer epidemiology, biomarkers & prevention, Vol.14(9), pp.2082-2086

2005

DOI: 10.1158/1055-9965.EPI-04-0757

PMID: 16172213

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Abstract

Purpose and Method: Several studies have suggested that physical inactivity and obesity increase the risk for colorectal neoplasia. In this study, we investigated the association of physical activity and body mass index (BMI) with the risk of different types of large bowel polyps. We did an observational analysis nested within a randomized double-blind placebo-controlled chemoprevention trial among patients with one or more recently resected histologically confirmed colorectal adenoma. Nine hundred thirty patients were randomized to calcium (1,200 mg/d, as carbonate) or placebo. Follow-up colonoscopies were conducted approximately 1 and 4 years after the qualifying examination. At study entry, we obtained each subject's current body weight and height, which we used to calculate BMI. After the second study colonoscopy, we asked subjects questions about their leisure time physical activity. Seven hundred eighty-seven subjects completed at least part of the physical activity questionnaire. Results: We found no association between measures of physical activity or BMI and tubular adenomas or hyperplastic polyps. However, among men, there were strong inverse associations observed between physical activity and advanced neoplastic polyps. Compared with men whose total daily energy expenditure was in the lowest tertile, those in the highest tertile had a risk ratio of 0.35 (95% confidence interval, 17-0.72); there was no similar reduction observed among women (risk ratio, 1.21; 95% confidence interval, 0.36-4.03; P for interaction = 0.04). Data Interpretations: We found a significant inverse relationship between several measures of physical activity and risk of advanced colorectal neoplasms, particularly among men. No associations were found between BMI and hyperplastic polyps, tubular adenomas, or advanced neoplastic polyps.

Tumors

Gastroenterology. Liver. Pancreas. Abdomen

Stomach. Duodenum. Small intestine. Colon. Rectum. Anus

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: The association of physical activity and body mass index with the risk of large bowel polyps
Creators: Kristin WALLACE - Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hamsphire, United States
John A BARON - Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hamsphire, United States
Margaret R KARAGAS - Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hamsphire, United States
Bernard F COLE - Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hamsphire, United States
Tim BYERS - Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, United States
Michael A BEACH - Department of Anesthesia, Dartmouth Hitchcock Medical Center, Lebanon, New Hamsphire, United States
Loretta H PEARSON - Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hamsphire, United States
Carol A BURKE - Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, United States
William B SILVERMAN - Department of Medicine, University of Iowa, Iowa City, Iowa, United States
Robert S SANDLER - Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States
Resource Type: Journal article
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.14(9), pp.2082-2086
DOI: 10.1158/1055-9965.EPI-04-0757
PMID: 16172213
NLM abbreviation: Cancer Epidemiol Biomarkers Prev
ISSN: 1055-9965
eISSN: 1538-7755
Publisher: American Association for Cancer Research
Language: English
Date published: 2005
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094350802771

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