Journal article
The association of physical activity before and after lymphoma diagnosis with survival outcomes
American journal of hematology, Vol.93(12), pp.1543-1550
12/2018
DOI: 10.1002/ajh.25288
PMCID: PMC6386179
PMID: 30230581
Abstract
The impact of physical activity (PA) on lymphoma survival is not known. The association of PA and change in PA with overall (OS), lymphoma-specific (LSS) and event-free (EFS) survival was evaluated in a prospective cohort of newly diagnosed lymphoma patients (2002-2012). We calculated Leisure Score Indexes (mLSI) from the self-reported usual adult PA (baseline) and at 3-years post-diagnosis (FU3), grouping patients by active vs insufficiently active by the American Cancer Society PA guidelines. Associations of PA with survival were assessed using hazard ratios (HRs) and 95% confidence intervals (CI) from Cox models stratified by lymphoma subtype, adjusted for age, sex, baseline BMI, and comorbidity score with change scores further adjusted for baseline PA. Three thousand sixty participants were evaluable at baseline and 1371 at FU3. Active patients had superior survival from baseline [HR (CI): OS 0.82 (0.72-0.94); LSS 0.74 (0.61-0.90); EFS 0.92 (0.82-1.02)] and FU3 [HR (CI): OS 0.64 (0.46-0.88); LSS 0.32 (0.18-0.59); EFS 0.82 (0.61-1.10)] compared to insufficiently active. An increase in mLSI from baseline to FU3 (vs stable mLSI) was associated with superior OS (HR = 0.70, CI 0.49-1.00) and LSS (HR = 0.49, CI 0.26-0.94).The continuous change in mLSI at FU3 was significantly associated with OS, LSS and EFS; maintained across subgroups and appeared linear. Higher PA among lymphoma patients at diagnosis and 3 years is significantly associated with OS, LSS, and EFS. Increasing PA after diagnosis is significantly associated with improved OS and LSS supporting an important role for PA in lymphoma survivorship and the need for intervention trials.
Details
- Title: Subtitle
- The association of physical activity before and after lymphoma diagnosis with survival outcomes
- Creators
- Priyanka A Pophali - Mayo Clinic in FloridaAndrew Ip - Emory UniversityMelissa C Larson - Mayo Clinic in FloridaAllison C Rosenthal - Mayo Clinic in FloridaMatthew J Maurer - Mayo ClinicChristopher R Flowers - Emory UniversityBrian K Link - University of IowaUmar Farooq - University of IowaAndrew L Feldman - Mayo ClinicCristine Allmer - Mayo Clinic in FloridaSusan L Slager - Mayo ClinicThomas E Witzig - Mayo ClinicThomas M Habermann - Mayo ClinicJonathon B Cohen - Emory UniversityJames R Cerhan - Mayo ClinicCarrie A Thompson - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.93(12), pp.1543-1550
- DOI
- 10.1002/ajh.25288
- PMID
- 30230581
- PMCID
- PMC6386179
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Grant note
- U01 CA195568 / NCI NIH HHS CA0972474 / Lymphoma SPORE P30 CA086862 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
- Language
- English
- Date published
- 12/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984359675902771
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