Journal article
The association of systemic microvascular changes with lung function and lung density: a cross-sectional study
PloS one, Vol.7(12), pp.e50224-e50224
2012
DOI: 10.1371/journal.pone.0050224
PMCID: PMC3527439
PMID: 23284634
Abstract
Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV(1)) (P<0.001) and FEV(1)/forced vital capacity (FVC) ratio (P = 0.04). Albumin-to-creatinine ratio was inversely associated with FEV(1) (P = 0.002) but not FEV(1)/FVC. Myocardial blood flow (n = 126) was associated with lower FEV(1) (P = 0.02), lower FEV(1)/FVC (P = 0.001) and greater percentage LAA (P = 0.04). Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition.
Details
- Title: Subtitle
- The association of systemic microvascular changes with lung function and lung density: a cross-sectional study
- Creators
- Bianca Harris - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of AmericaRonald KleinMichael Jerosch-HeroldEric A HoffmanFiras S AhmedDavid R Jacobs JrBarbara E K KleinTien Y WongJoao A C LimaMary Frances CotchR Graham Barr
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.7(12), pp.e50224-e50224
- DOI
- 10.1371/journal.pone.0050224
- PMID
- 23284634
- PMCID
- PMC3527439
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- N01HC95169 / NHLBI NIH HHS ZIA EY000403-13 / Intramural NIH HHS ZIA EY000403-15 / Intramural NIH HHS ZIA EY000403-14 / Intramural NIH HHS Z01 EY000403-06 / Intramural NIH HHS Z99 EY999999 / Intramural NIH HHS R01-HL093081 / NHLBI NIH HHS Z01 EY000403-07 / Intramural NIH HHS R01 HL093081 / NHLBI NIH HHS R01-HL075476 / NHLBI NIH HHS UL1-TR000040 / NCATS NIH HHS R01-HL077612 / NHLBI NIH HHS N01-HC95159-HC95169 / NHLBI NIH HHS ZIA EY000403-09 / Intramural NIH HHS ZIA EY000403-08 / Intramural NIH HHS R01 HL077612 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS R01 HL075476 / NHLBI NIH HHS ZIA EY000403-11 / Intramural NIH HHS ZIA EY000403-12 / Intramural NIH HHS ZIA EY000403-10 / Intramural NIH HHS
- Language
- English
- Date published
- 2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051523802771
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