The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women

Robert Philibert; Kristin Caspers; Douglas Langbehn; Edward P Troughton; Rebecca Yucuis; Harinder K Sandhu; Remi J Cadoret

doi:10.1002/ajmg.b.20062

Back

The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women

Journal article

Peer reviewed

The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women

Robert Philibert, Kristin Caspers, Douglas Langbehn, Edward P Troughton, Rebecca Yucuis, Harinder K Sandhu and Remi J Cadoret

American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.121B(1), pp.39-43

08/15/2003

DOI: 10.1002/ajmg.b.20062

PMID: 12898573

View Online

Abstract

Major depressive disorder (MDD) and substance use disorders (SUD) are complex behavioral disorders with 40-50% heritability. Recently, Zubenko and colleagues reported that the 124 bp allele of D2S2944, a tetranucleotide repeat marker on 2q35, is strongly associated with recurrent, early onset MDD (RE-MDD) and alcohol use disorders in women. To test this hypothesis, we examined the association of the 124 bp allele in a subset of 171 adoptees from the Iowa Adoption Studies, a population with high rates of MDD and SUD. We report that in our population, the 124 bp allele significantly associated with RE-MDD in women. There was slight evidence of an increased of SUD in women with the 124 bp allele with the rate of cannabis use disorders reaching statistical significance (P < 0.04) before correction for multiple comparisons. Given the history of prior studies implicating 2q35 as a locus encoding vulnerability to co-morbid alcoholism and depression, these findings strongly suggest that sequence variation conveying increased susceptibility to MDD and possibly SUD is in close proximity to D2S2944.

Chromosomes, Human, Pair 2

Depressive Disorder, Major - genetics

Humans

Middle Aged

Adolescent

Adult

Female

Male

Genetic Markers

Details

Title: Subtitle: The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women
Creators: Robert Philibert - Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242-1000, USA. robert-philibert@uiowa.edu
Kristin Caspers
Douglas Langbehn
Edward P Troughton
Rebecca Yucuis
Harinder K Sandhu
Remi J Cadoret
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.121B(1), pp.39-43
DOI: 10.1002/ajmg.b.20062
PMID: 12898573
NLM abbreviation: Am J Med Genet B Neuropsychiatr Genet
ISSN: 1552-4841
eISSN: 1552-485X
Publisher: United States
Grant note: K08 MH64714 / NIMH NIH HHS R01 DA05821 / NIDA NIH HHS
Language: English
Date published: 08/15/2003
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984004191802771

Metrics

17 Record Views

18 Times Cited - Web of Science