Journal article
The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation
Cell cycle (Georgetown, Tex.), Vol.15(16), pp.2124-2134
08/17/2016
DOI: 10.1080/15384101.2016.1196306
PMCID: PMC4993542
PMID: 27294844
Abstract
The centrosome is the major microtubule-organizing center in animal cells but is dispensable for proper microtubule spindle formation in many biological contexts and is thus thought to fulfill additional functions. Recent observations suggest that the centrosome acts as a scaffold for proteasomal degradation in the cell to regulate a variety of biological processes including cell fate acquisition, cell cycle control, stress response, and cell morphogenesis. Here, we review the body of studies indicating a role for the centrosome in promoting proteasomal degradation of ubiquitin-proteasome substrates and explore the functional relevance of this system in different biological contexts. We discuss a potential role for the centrosome in coordinating local degradation of proteasomal substrates, allowing cells to achieve stringent spatiotemporal control over various signaling processes.
Details
- Title: Subtitle
- The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation
- Creators
- Setu M Vora - Department of Biological Sciences, University of IowaBryan T Phillips - Department of Biological Sciences, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Cell cycle (Georgetown, Tex.), Vol.15(16), pp.2124-2134
- Publisher
- Taylor & Francis
- DOI
- 10.1080/15384101.2016.1196306
- PMID
- 27294844
- PMCID
- PMC4993542
- ISSN
- 1538-4101
- eISSN
- 1551-4005
- Language
- English
- Date published
- 08/17/2016
- Academic Unit
- Biology
- Record Identifier
- 9984217427302771
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