The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers

David C Ishizawar; Karen M Janosko; Jeffrey J Teuteberg; Linda M Cadaret; Michael A Mathier; Dennis M McNamara

doi:10.1111/j.1752-8062.2008.00020.x

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The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers

Journal article

Open access

The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers

David C Ishizawar, Karen M Janosko, Jeffrey J Teuteberg, Linda M Cadaret, Michael A Mathier and Dennis M McNamara

Clinical and translational science, Vol.1(2), pp.151-154

09/2008

DOI: 10.1111/j.1752-8062.2008.00020.x

PMCID: PMC5439562

PMID: 20443839

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Abstract

The role of beta-receptor selectivity for the interaction between the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and beta-blocker therapy was investigated in 479 subjects with left ventricular dysfunction. Subjects were separated into no beta-blocker, beta1 -selective, and nonselective beta-blocker treatment groups. The D allele adversely affected transplant-free survival for subjects not on beta-blockers (p= 0.004). Treatment with selective beta1-blockers eliminated the impact of the D allele (p= 0.51) in a manner similar to nonselective beta1,2-blockers (p= 0.80). Treatment with beta1-blockers was sufficient to eliminate the adverse impact of the ACE D allele, suggesting this pharmacogenetic interaction is mediated through the beta1-receptor.

Adrenergic beta-Antagonists - classification

Pharmacogenetics

Demography

Humans

Middle Aged

Genotype

INDEL Mutation - genetics

Male

Receptors, Adrenergic, beta-1 - metabolism

Adrenergic beta-1 Receptor Antagonists

Adrenergic beta-Antagonists - pharmacology

Disease-Free Survival

Peptidyl-Dipeptidase A - genetics

Alleles

Female

Cohort Studies

Details

Title: Subtitle: The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers
Creators: David C Ishizawar - Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Karen M Janosko
Jeffrey J Teuteberg
Linda M Cadaret
Michael A Mathier
Dennis M McNamara
Resource Type: Journal article
Publication Details: Clinical and translational science, Vol.1(2), pp.151-154
DOI: 10.1111/j.1752-8062.2008.00020.x
PMID: 20443839
PMCID: PMC5439562
NLM abbreviation: Clin Transl Sci
eISSN: 1752-8062
Grant note: K24 HL069912 / NHLBI NIH HHS K24 HL 69912 / NHLBI NIH HHS R01 HL75038 / NHLBI NIH HHS
Language: English
Date published: 09/2008
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984094712902771

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