Journal article
The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature
Laryngoscope investigative otolaryngology, Vol.6(3), pp.458-468
06/2021
DOI: 10.1002/lio2.553
PMCID: PMC8223465
PMID: 34195368
Abstract
Objective
Radiation therapy is a mainstay in the treatment of numerous neoplasms. Numerous publications have reported good clinical outcomes for primary radiation therapy for Vestibular Schwannomas (VS). However, there are relatively few pathologic specimens of VSs available to evaluate post‐radiation, which has led to a relative dearth in research on the cellular mechanisms underlying the effects of radiation therapy on VSs.
Methods
Here we review the latest literature on the complex biological effects of radiation therapy on these benign tumors—including resistance to oxidative stress, mechanisms of DNA damage repair, alterations in normal growth factor pathways, changes in surrounding vasculature, and alterations in immune responses following radiation.
Results
Although VSs are highly radioresistant, radiotherapy is often successful in arresting their growth.
Conclusion
By better understanding the mechanisms underlying these effects, we could potentially harness such mechanisms in the future to potentiate the clinical effects of radiotherapy on VSs.
Level of Evidence
N/A.
Although Vestibular Schwannomas (VS) are highly radioresistant, radiotherapy is often successful in arresting their growth. Here we review the latest literature on the complex biological effects of radiation therapy on these benign tumors—including resistance to oxidative stress, mechanisms of DNA damage repair, alterations in normal growth factor pathways, changes in surrounding vasculature, and alterations in immune responses following radiation. By better understanding the mechanisms underlying these effects, we could potentially harness such mechanisms in the future to potentiate the clinical effects of radiotherapy on VSs.
Details
- Title: Subtitle
- The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature
- Creators
- Mark C. Dougherty - University of Iowa Hospitals and ClinicsSeiji B. Shibata - University of Southern CaliforniaMarlan R. Hansen - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Laryngoscope investigative otolaryngology, Vol.6(3), pp.458-468
- DOI
- 10.1002/lio2.553
- PMID
- 34195368
- PMCID
- PMC8223465
- NLM abbreviation
- Laryngoscope Investig Otolaryngol
- ISSN
- 2378-8038
- eISSN
- 2378-8038
- Publisher
- John Wiley & Sons, Inc
- Number of pages
- 11
- Grant note
- National Institutes of Health (NCATS U54 TR001013)
- Language
- English
- Date published
- 06/2021
- Academic Unit
- Molecular Physiology and Biophysics; Neurosurgery; Otolaryngology
- Record Identifier
- 9984297596402771
Metrics
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