Journal article
The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance
Cell metabolism, Vol.12(5), pp.431-442
11/03/2010
DOI: 10.1016/j.cmet.2010.09.011
PMCID: PMC2994017
PMID: 21035755
Abstract
The renin-angiotensin system (RAS), in addition to its endocrine functions, plays a role within individual tissues such as the brain. The brain RAS is thought to control blood pressure through effects on fluid intake, vasopressin release, and sympathetic nerve activity (SNA), and may regulate metabolism through mechanisms which remain undefined. We used a double-transgenic mouse model that exhibits brain-specific RAS activity to examine mechanisms contributing to fluid and energy homeostasis. The mice exhibit high fluid turnover through increased adrenal steroids, which is corrected by adrenalectomy and attenuated by mineralocorticoid receptor blockade. They are also hyperphagic but lean because of a marked increase in body temperature and metabolic rate, mediated by increased SNA and suppression of the circulating RAS. β-adrenergic blockade or restoration of circulating angiotensin-II, but not adrenalectomy, normalized metabolic rate. Our data point to contrasting mechanisms by which the brain RAS regulates fluid intake and energy expenditure.
Details
- Title: Subtitle
- The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance
- Creators
- Justin L Grobe - Department of Internal Medicine, University of Iowa, Iowa City, 52242, USAConnie L GrobeTerry G BeltzScott G WestphalDonald A MorganDi XuWillem J de LangeHuiping LiKoji SakaiDaniel R ThedensLisa A CassisKamal RahmouniAllyn L MarkAlan Kim JohnsonCurt D Sigmund
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.12(5), pp.431-442
- DOI
- 10.1016/j.cmet.2010.09.011
- PMID
- 21035755
- PMCID
- PMC2994017
- NLM abbreviation
- Cell Metab
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Publisher
- United States
- Grant note
- R01 DK066086 / NIDDK NIH HHS HL014388 / NHLBI NIH HHS HL084207 / NHLBI NIH HHS R01 HL061446 / NHLBI NIH HHS MH080241 / NIMH NIH HHS R37 HL048058 / NHLBI NIH HHS K99 HL098276 / NHLBI NIH HHS HL048058 / NHLBI NIH HHS HL073085 / NHLBI NIH HHS R00 HL098276 / NHLBI NIH HHS R01 MH080241 / NIMH NIH HHS P01 NS024621 / NINDS NIH HHS HL061446 / NHLBI NIH HHS P01 HL014388 / NHLBI NIH HHS HL098276 / NHLBI NIH HHS R01 HL048058 / NHLBI NIH HHS P01 HL084207 / NHLBI NIH HHS DK066086 / NIDDK NIH HHS R01 HL073085 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/03/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984002343002771
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