The cAMP pathway and pain: potential targets for drug development

David A Skyba; Rajan Radhakrishnan; Marie K Hoeger Bement; Kathleen A Sluka

doi:10.1016/j.ddmod.2004.07.003

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The cAMP pathway and pain: potential targets for drug development

Journal article

Peer reviewed

The cAMP pathway and pain: potential targets for drug development

David A Skyba, Rajan Radhakrishnan, Marie K Hoeger Bement and Kathleen A Sluka

Drug discovery today. Disease models, Vol.1(2), pp.115-119

2004

DOI: 10.1016/j.ddmod.2004.07.003

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Abstract

Activation of the cAMP pathway in the central nervous system produces hyperalgesia and inhibition of this pathway reduces hyperalgesia in inflammatory, non-inflammatory, and neuropathic pain models. There are increases in phosphorylation of the transcription factor, CREB, which might initiate gene transcription of “pain genes”. There are also increases in the phosphorylation of glutamate receptor subunit proteins that probably increase insertion of receptors into the membrane and increase channel conductance. Min Zhuo—University of Toronto, Ontario, Canada Cyclic AMP (cAMP) is a key intracellular second messenger for triggering long-term changes in cells and neurons, such long-term changes are thought to be important for physiological functions such as learning and memory and pathological processes including chronic pain. In this manuscript, Kathleen Sluka and colleagues provide an overview of cAMP-related signal processing along pain transmission and modulation pathways, from periphery to anterior cingulate cortex. It is proposed that cAMP-dependent signaling pathways contribute to long-term enhancement of central nociceptive transmission and perception. Sluka and colleagues propose cAMP signaling pathways as potential targets for developing drugs for chronic pain.

Details

Title: Subtitle: The cAMP pathway and pain: potential targets for drug development
Creators: David A Skyba - Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
Rajan Radhakrishnan - Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA 52242, USA
Marie K Hoeger Bement - Department of Physical Therapy, Marquette University, Milwaukee, WI 53201, USA
Kathleen A Sluka - Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Drug discovery today. Disease models, Vol.1(2), pp.115-119
DOI: 10.1016/j.ddmod.2004.07.003
ISSN: 1740-6757
eISSN: 1740-6757
Publisher: Elsevier Ltd
Language: English
Date published: 2004
Academic Unit: Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
Record Identifier: 9984070301702771

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