Journal article
The cAMP–Protein Kinase A Signal Transduction Pathway Modulates Ethanol Consumption and Sedative Effects of Ethanol
The Journal of neuroscience, Vol.21(14), pp.5297-5303
07/15/2001
DOI: 10.1523/JNEUROSCI.21-14-05297.2001
PMCID: PMC6762861
PMID: 11438605
Abstract
Ethanol and other drugs of abuse modulate cAMP-PKA signaling within the mesolimbic reward pathway. To understand the role of the cAMP-PKA signal transduction in mediating the effects of ethanol, we have studied ethanol consumption and the sedative effects of ethanol in three lines of genetically modified mice. We report that mice with the targeted disruption of one Gsalpha allele as well as mice with reduced neuronal PKA activity have decreased alcohol consumption compared with their wild-type littermates. Genetic reduction of cAMP-PKA signaling also makes mice more sensitive to the sedative effects of ethanol, although plasma ethanol concentrations are unaffected. In contrast, mice with increased adenylyl cyclase activity resulting from the transgenic expression of a constitutively active form of Gsalpha in neurons within the forebrain are less sensitive to the sedative effects of ethanol. Thus, the cAMP-PKA signal transduction pathway is critical in modulating sensitivity to the sedative effects of ethanol as well as influencing alcohol consumption.
Details
- Title: Subtitle
- The cAMP–Protein Kinase A Signal Transduction Pathway Modulates Ethanol Consumption and Sedative Effects of Ethanol
- Creators
- Gary WandMichael LevineLarry ZweifelWilliam SchwindingerTed Abel
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.21(14), pp.5297-5303
- DOI
- 10.1523/JNEUROSCI.21-14-05297.2001
- PMID
- 11438605
- PMCID
- PMC6762861
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 07/15/2001
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065831502771
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