Journal article
The calcium signal and neutrophil activation
Clinical biochemistry, Vol.23(2), pp.159-166
1990
DOI: 10.1016/0009-9120(90)80030-M
PMID: 2197028
Abstract
The cytosolic free calcium concentration, [Ca
2+]
i in phagocytic cells (
e.g. neutrophils, human leukemic cell line HL-60) is an important determinant of cellular activity. In resting phagocytes [Ca
2+]
i is low (approximately 100 nM), but in response to occupation of cell surface receptors, it rises to micromolar levels, thereby activating a variety of cellular functions. The increases in [Ca
2+]
i consist of two components: an immediate that is independent of extracellular Ca
2+, and a more delayed that is abolished by the removal of extracellular Ca
2+. These two components reflect the involvement of two subcellular structures in intracellular Ca
2+ homeostasis: an intracellular Ca
2+ store, referred to as the calciosome; and the plasma membrane. The function of the intracellular Ca
2+ - store depends on a Ca
2+ -pump, functionally and immunologically related to the cardiac sarcoplasmic reticulum Ca
2+ -ATPase, a Ca
2+ -storage protein, similar to muscle calsequestrin, and a Ca
2+ - release channel, which is sensitive to inositol 1,4,5-trisphosphate. The Ca
2+ -regulatory function of the plasma membrane depends on a Ca
2+ pump, similar to the erythrocyte-type Ca
2+ -ATPase, and a Ca
2+ channel; the activity of the Ca
2+ channel is closely coupled to phosphatidylinositol turnover.
Details
- Title: Subtitle
- The calcium signal and neutrophil activation
- Creators
- Karl-Heinz Krause - Department of Internal Medicine, Division of Infectious Diseases and Pulmonary Diseases, University of Iowa College of Medicine, Iowa City, IA, USAKevin P Campbell - Department of Internal Medicine, Division of Infectious Diseases and Pulmonary Diseases, University of Iowa College of Medicine, Iowa City, IA, USAMichael J Welsh - Department of Internal Medicine, Division of Infectious Diseases and Pulmonary Diseases, University of Iowa College of Medicine, Iowa City, IA, USADaniel P Lew - Department of Internal Medicine, Division of Infectious Diseases and Pulmonary Diseases, University of Iowa College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Clinical biochemistry, Vol.23(2), pp.159-166
- DOI
- 10.1016/0009-9120(90)80030-M
- PMID
- 2197028
- NLM abbreviation
- Clin Biochem
- ISSN
- 0009-9120
- eISSN
- 1873-2933
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1990
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020865102771
Metrics
26 Record Views