Journal article
The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae
Communicative & integrative biology, Vol.2(3), pp.233-235
2009
DOI: 10.4161/cib.2.3.8097
PMCID: PMC2717530
PMID: 19641740
Abstract
The unfolded protein response (UPR) is an intracellular signaling pathway that regulates the cellular response to the accumulation of misfolded proteins in eukaryotes. Our group has demonstrated that cell wall stress activates UPR in yeast through signals transmitted by the cell wall integrity (CWI) mitogen-activated protein (MAP) kinase cascade. The UPR is required to maintain cell wall integrity; mutants lacking a functional UPR have defects in cell wall biosynthesis and are hypersensitive to cell wall-directed antifungal drugs. Since ER stress also activates CWI signaling, we propose that ER and cell wall stress responses are coordinated by CWI and UPR signaling pathways in order to protect cells against these related stressors. Further investigation of the mechanisms of this coordinate regulation may lead to improved cell wall-directed antifungal therapies.
Details
- Title: Subtitle
- The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae
- Creators
- Damian J Krysan - Departments of Pediatrics and Microbiology/Immunology; University of Rochester School of Medicine and Dentistry; Rochester, NY USA
- Resource Type
- Journal article
- Publication Details
- Communicative & integrative biology, Vol.2(3), pp.233-235
- Publisher
- Landes Bioscience
- DOI
- 10.4161/cib.2.3.8097
- PMID
- 19641740
- PMCID
- PMC2717530
- ISSN
- 1942-0889
- eISSN
- 1942-0889
- Language
- English
- Date published
- 2009
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093459202771
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