The cellular and molecular bases of leptin and ghrelin resistance in obesity

Huxing Cui; Miguel López; Kamal Rahmouni

doi:10.1038/nrendo.2016.222

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The cellular and molecular bases of leptin and ghrelin resistance in obesity

Journal article

Open access

Peer reviewed

The cellular and molecular bases of leptin and ghrelin resistance in obesity

Huxing Cui, Miguel López and Kamal Rahmouni

Nature reviews. Endocrinology, Vol.13(6), pp.338-351

06/2017

DOI: 10.1038/nrendo.2016.222

PMCID: PMC8904083

PMID: 28232667

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https://www.ncbi.nlm.nih.gov/pmc/articles/8904083View

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Abstract

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases and certain types of cancer, arises from a chronic positive energy balance that is often due to unlimited access to food and an increasingly sedentary lifestyle on the background of a genetic and epigenetic vulnerability. Our understanding of the humoral and neuronal systems that mediate the control of energy homeostasis has improved dramatically in the past few decades. However, our ability to develop effective strategies to slow the current epidemic of obesity has been hampered, largely owing to the limited knowledge of the mechanisms underlying resistance to the action of metabolic hormones such as leptin and ghrelin. The development of resistance to leptin and ghrelin, hormones that are crucial for the neuroendocrine control of energy homeostasis, is a hallmark of obesity. Intensive research over the past several years has yielded tremendous progress in our understanding of the cellular pathways that disrupt the action of leptin and ghrelin. In this Review, we discuss the molecular mechanisms underpinning resistance to leptin and ghrelin and how they can be exploited as targets for pharmacological management of obesity.

Ghrelin - physiology

Signal Transduction

Humans

Cyclic AMP

Homeostasis

Ghrelin - pharmacology

Obesity - physiopathology

Receptors, Ghrelin - physiology

Hypothalamus

Leptin - physiology

Animals

Receptors, Leptin - physiology

Leptin - pharmacology

Energy Metabolism - physiology

Drug Resistance

Details

Title: Subtitle: The cellular and molecular bases of leptin and ghrelin resistance in obesity
Creators: Huxing Cui - Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242, USA
Miguel López - Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain
Kamal Rahmouni - Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242, USA
Resource Type: Journal article
Publication Details: Nature reviews. Endocrinology, Vol.13(6), pp.338-351
DOI: 10.1038/nrendo.2016.222
PMID: 28232667
PMCID: PMC8904083
NLM abbreviation: Nat Rev Endocrinol
ISSN: 1759-5029
eISSN: 1759-5037
Publisher: England
Grant note: P01 HL084207 / NHLBI NIH HHS R21 MH109920 / NIMH NIH HHS R01 HL127673 / NHLBI NIH HHS
Language: English
Date published: 06/2017
Academic Unit: Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040267702771

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