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The changing relationship between bronchopulmonary dysplasia and cognition in very preterm infants
Journal article   Open access   Peer reviewed

The changing relationship between bronchopulmonary dysplasia and cognition in very preterm infants

Jane E. Brumbaugh, Tarah T. Colaizy, Neel M. Patel and Jonathan M. Klein
ACTA PAEDIATRICA, Vol.107(8), pp.1339-1344
08/01/2018
DOI: 10.1111/apa.14219
PMID: 29333635
url
https://doi.org/10.1111/apa.14219View
Published (Version of record) Open Access

Abstract

Aim: To characterise the relationship between bronchopulmonary dysplasia (BPD) severity and cognition in the post-surfactant era. Methods: This was a single-centre retrospective analysis of a cohort of infants born 2009-2012. Inclusion criteria were as follows: admission within 48 hours of birth, gestational age 22-0/7-31-6/7 weeks, birthweight 400-1500 g and Bayley Scales of Infant and Toddler Development-III testing at 18-26 months corrected age. Infants (n = 151) were classified by BPD severity with the NIH Workshop definition. Generalised linear modelling and multivariate logistic regression were performed. Results: Bayley cognitive score was not associated with BPD severity in univariate (p = 0.053) or multivariate (p = 0.503) analysis. About 27% of infants with no/mild BPD, 33% of infants with moderate BPD and 40% of infants with severe BPD had a cognitive score < 85. There was no difference in the odds of cognitive score < 85 based on BPD severity in univariate (p = 0.485) or multivariate analysis (p = 0.225). All infants with cognitive score < 70 had severe BPD, although the association between cognitive score < 70 and BPD severity was not significant. Conclusion: We found no independent effect of BPD severity level on cognition. The likelihood of a cognitive score < 85 was not associated with BPD severity.
 Life Sciences & Biomedicine Pediatrics Science & Technology

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