Journal article
The cholinergic system and neostriatal memory functions
Behavioural brain research, Vol.221(2), pp.412-423
2011
DOI: 10.1016/j.bbr.2010.11.047
PMCID: PMC3075367
PMID: 21129408
Abstract
▶ The striatal cholinergic and dopaminergic systems modulate each other's function. ▶ Nicotinic and muscarinic cholinergic receptors facilitate and attenuate GABA release respectively. ▶ The striatal cholinergic system serves in a diverse set of cognitive functions. ▶ Aging reduces striatal nicotinic and muscarinic cholinergic receptor functioning.
The striatum is one of the major forebrain regions that strongly expresses muscarinic and nicotinic cholinergic receptors. This article reviews the current knowledge and our new findings about the striatal cholinoceptive organization and its role in a variety of cognitive functions. Pharmacological and genetic manipulations have indicated that the cholinergic and dopaminergic system in the striatum modulate each other's function. In addition to modulating the dopaminergic system, nicotinic cholinergic receptors facilitate GABA release, whereas muscarinic receptors attenuate GABA release. The striatal cholinergic system has also been implicated in various cognitive functions including procedural learning and intradimensional set shifting. Together, these data indicate that the cholinergic system in the striatum is involved in a diverse set of cognitive functions through interactions with other neurotransmitter systems including the dopaminergic and GABAergic systems.
Details
- Title: Subtitle
- The cholinergic system and neostriatal memory functions
- Creators
- Robbert Havekes - Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USATed Abel - Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USAEddy A Van der Zee - Department of Molecular Neurobiology, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
- Resource Type
- Journal article
- Publication Details
- Behavioural brain research, Vol.221(2), pp.412-423
- DOI
- 10.1016/j.bbr.2010.11.047
- PMID
- 21129408
- PMCID
- PMC3075367
- NLM abbreviation
- Behav Brain Res
- ISSN
- 0166-4328
- eISSN
- 1872-7549
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2011
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065838002771
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