The clinical features of the overlap between COPD and asthma

Megan Hardin; Edwin K Silverman; R Graham Barr; Nadia N Hansel; Joyce D Schroeder; Barry J Make; James D Crapo; Craig P Hersh; COPDGene Investigators

doi:10.1186/1465-9921-12-127

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The clinical features of the overlap between COPD and asthma

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The clinical features of the overlap between COPD and asthma

Megan Hardin, Edwin K Silverman, R Graham Barr, Nadia N Hansel, Joyce D Schroeder, Barry J Make, James D Crapo, Craig P Hersh and COPDGene Investigators

Respiratory research, Vol.12(1), pp.127-127

01/01/2011

DOI: 10.1186/1465-9921-12-127

PMCID: PMC3204243

PMID: 21951550

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Abstract

Background The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history.

Asthma

Airway hyperresponsiveness

Chronic obstructive pulmonary disease

emphysema

Exacerbation

Gas-trapping

Details

Title: Subtitle: The clinical features of the overlap between COPD and asthma
Creators: Megan Hardin - Brigham and Women's Hospital
Edwin K Silverman - Brigham and Women's Hospital
R Graham Barr - Columbia University
Nadia N Hansel - Johns Hopkins University
Joyce D Schroeder - National Jewish Health
Barry J Make - National Jewish Health
James D Crapo - National Jewish Health
Craig P Hersh - Brigham and Women's Hospital
COPDGene Investigators
Contributors: Eric Hoffman (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Respiratory research, Vol.12(1), pp.127-127
DOI: 10.1186/1465-9921-12-127
PMID: 21951550
PMCID: PMC3204243
NLM abbreviation: Respir Res
ISSN: 1465-9921
eISSN: 1465-993X
Publisher: BioMed Central
Language: English
Date published: 01/01/2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984318817202771

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