The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group

Optic Neuritis Study Group; James J Corbett; H Stanley Thompson; Carmen Musser; Randy H Kardon; Thomas   Farrell; Neill R Graff-Redford; Jose Biller; Patricia K Johnston; Mark A Ross; Gavin W Mitchell; Alan K Kimura; Judi Delsing; Connie Fountain

doi:10.1001/archopht.1991.01080120057025

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The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group

Optic Neuritis Study Group, James J Corbett, H Stanley Thompson, Carmen Musser, Randy H Kardon, Thomas Farrell, Neill R Graff-Redford, Jose Biller, Patricia K Johnston, Mark A Ross, …

Archives of ophthalmology (1960), Vol.109(12), pp.1673-1678

12/1991

DOI: 10.1001/archopht.1991.01080120057025

PMID: 1841573

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Abstract

Clinical trial The baseline characteristics of 448 eligible patients entered into the Optic Neuritis Treatment Trial are described in an effort to summarize the clinical profile of acute optic neuritis. A total of 77.2% of the patients were women. Mean age was 31.8 years. Pain accompanied the visual loss in 92.2% of cases. The optic disc appeared swollen in 35.3% of the patients and normal in 64.7%. A wide variety of visual field defects were present. Abnormalities in asymptomatic fellow eyes were noted, particularly on perimetry. Magnetic resonance imaging showed changes consistent with demyelination of the brain in 48.7% of the patients. Magnetic resonance imaging, serologic studies (such as the antinuclear antibody test and the fluorescent treponemal antibody absorption test), chest roentgenography, and lumbar puncture were of limited utility in defining a cause for visual loss other than optic neuritis associated with demyelinative disease.

Magnetic Resonance Imaging

Humans

Middle Aged

Male

Optic Neuritis - diagnosis

Vision Tests

Multiple Sclerosis - complications

Optic Neuritis - physiopathology

Adolescent

Adult

Female

Radiography, Thoracic

Serologic Tests

Details

Title: Subtitle: The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group
Creators: Optic Neuritis Study Group (Author)
James J Corbett (Contributor) - University of Mississippi Medical Center
H Stanley Thompson (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
Carmen Musser (Contributor)
Randy H Kardon (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
Thomas Farrell (Contributor)
Neill R Graff-Redford (Contributor)
Jose Biller
Patricia K Johnston (Contributor)
Mark A Ross (Contributor)
Gavin W Mitchell (Contributor)
Alan K Kimura
Judi Delsing (Contributor)
Connie Fountain (Contributor)
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.109(12), pp.1673-1678
DOI: 10.1001/archopht.1991.01080120057025
PMID: 1841573
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Grant note: EYO7212 / NEI NIH HHS EYO7460 / NEI NIH HHS EYO7461 / NEI NIH HHS
Language: English
Date published: 12/1991
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979916402771

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