The collaborative study on the genetics of alcoholism: Genetics

Emma C. Johnson; Jessica E. Salvatore; Dongbing Lai; Alison K. Merikangas; John I. Nurnberger; Jay A. Tischfield; Xiaoling Xuei; Chella Kamarajan; Leah Wetherill; John P. Rice; John R. Kramer; Samuel Kuperman; Tatiana Foroud; Paul A. Slesinger; Alison M. Goate; Bernice Porjesz; Danielle M. Dick; Howard J. Edenberg; Arpana Agrawal; COGA Collaborators

doi:10.1111/gbb.12856

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The collaborative study on the genetics of alcoholism: Genetics

Journal article

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The collaborative study on the genetics of alcoholism: Genetics

Emma C. Johnson, Jessica E. Salvatore, Dongbing Lai, Alison K. Merikangas, John I. Nurnberger, Jay A. Tischfield, Xiaoling Xuei, Chella Kamarajan, Leah Wetherill, John P. Rice, …

Genes, brain and behavior, Vol.22(5), e12856

10/2023

DOI: 10.1111/gbb.12856

PMCID: PMC10550788

PMID: 37387240

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Abstract

This review describes the genetic approaches and results from the family-based Collaborative Study on the Genetics of Alcoholism (COGA). COGA was designed during the linkage era to identify genes affecting the risk for alcohol use disorder (AUD) and related problems, and was among the first AUD-focused studies to subsequently adopt a genome-wide association (GWAS) approach. COGA's family-based structure, multimodal assessment with gold-standard clinical and neurophysiological data, and the availability of prospective longitudinal phenotyping continues to provide insights into the etiology of AUD and related disorders. These include investigations of genetic risk and trajectories of substance use and use disorders, phenome-wide association studies of loci of interest, and investigations of pleiotropy, social genomics, genetic nurture, and within-family comparisons. COGA is one of the few AUD genetics projects that includes a substantial number of participants of African ancestry. The sharing of data and biospecimens has been a cornerstone of the COGA project, and COGA is a key contributor to large-scale GWAS consortia. COGA's wealth of publicly available genetic and extensive phenotyping data continues to provide a unique and adaptable resource for our understanding of the genetic etiology of AUD and related traits.

Details

Title: Subtitle: The collaborative study on the genetics of alcoholism: Genetics
Creators: Emma C. Johnson - Washington University in St. Louis
Jessica E. Salvatore - Rutgers, The State University of New Jersey
Dongbing Lai - Indiana University
Alison K. Merikangas - Children's Hospital of Philadelphia
John I. Nurnberger - Indiana University
Jay A. Tischfield - Rutgers, The State University of New Jersey
Xiaoling Xuei - Indiana University
Chella Kamarajan - State University of New York
Leah Wetherill - Indiana University
John P. Rice - Washington University in St. Louis
John R. Kramer - University of Iowa
Samuel Kuperman - University of Iowa
Tatiana Foroud - Indiana University
Paul A. Slesinger - Icahn School of Medicine at Mount Sinai
Alison M. Goate - Icahn School of Medicine at Mount Sinai
Bernice Porjesz - State University of New York
Danielle M. Dick - Rutgers, The State University of New Jersey
Howard J. Edenberg - Indiana University
Arpana Agrawal - Washington University in St. Louis
COGA Collaborators
Resource Type: Journal article
Publication Details: Genes, brain and behavior, Vol.22(5), e12856
DOI: 10.1111/gbb.12856
PMID: 37387240
PMCID: PMC10550788
NLM abbreviation: Genes Brain Behav
ISSN: 1601-1848
eISSN: 1601-183X
Grant note: DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: R01AA028064, U10AA008401; DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: K01DA051759
Language: English
Electronic publication date: 06/30/2023
Date published: 10/2023
Academic Unit: Psychiatry
Record Identifier: 9984442223802771

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