Journal article
The collaborative study on the genetics of alcoholism: Brain function
Genes, brain and behavior, Vol.22(5), e12862
10/2023
DOI: 10.1111/gbb.12862
PMCID: PMC10550791
PMID: 37587903
Abstract
Alcohol use disorder (AUD) and related health conditions result from a complex interaction of genetic, neural and environmental factors, with differential impacts across the lifespan. From its inception, the Collaborative Study on the Genetics of Alcoholism (COGA) has focused on the importance of brain function as it relates to the risk and consequences of alcohol use and AUD, through the examination of noninvasively recorded brain electrical activity and neuropsychological tests. COGA's sophisticated neurophysiological and neuropsychological measures, together with rich longitudinal, multi-modal family data, have allowed us to disentangle brain-related risk and resilience factors from the consequences of prolonged and heavy alcohol use in the context of genomic and social-environmental influences over the lifespan. COGA has led the field in identifying genetic variation associated with brain functioning, which has advanced the understanding of how genomic risk affects AUD and related disorders. To date, the COGA study has amassed brain function data on over 9871 participants, 7837 with data at more than one time point, and with notable diversity in terms of age (from 7 to 97), gender (52% female), and self-reported race and ethnicity (28% Black, 9% Hispanic). These data are available to the research community through several mechanisms, including directly through the NIAAA, through dbGAP, and in collaboration with COGA investigators. In this review, we provide an overview of COGA's data collection methods and specific brain function measures assessed, and showcase the utility, significance, and contributions these data have made to our understanding of AUD and related disorders, highlighting COGA research findings.
Details
- Title: Subtitle
- The collaborative study on the genetics of alcoholism: Brain function
- Creators
- Jacquelyn L Meyers - SUNY Downstate Health Sciences UniversitySarah J Brislin - Rutgers, The State University of New JerseyChella Kamarajan - SUNY Downstate Health Sciences UniversityMartin H Plawecki - Indiana University BloomingtonDavid Chorlian - SUNY Downstate Health Sciences UniversityAndrey Anohkin - Washington University in St. LouisSamuel Kuperman - University of IowaAlison Merikangas - Children's Hospital of PhiladelphiaGayathri Pandey - SUNY Downstate Health Sciences UniversitySivan Kinreich - SUNY Downstate Health Sciences UniversityAshwini Pandey - SUNY Downstate Health Sciences UniversityHoward J Edenberg - Indiana University BloomingtonKathleen K Bucholz - Washington University in St. LouisLaura Almasy - University of PennsylvaniaBernice Porjesz - SUNY Downstate Health Sciences University
- Resource Type
- Journal article
- Publication Details
- Genes, brain and behavior, Vol.22(5), e12862
- DOI
- 10.1111/gbb.12862
- PMID
- 37587903
- PMCID
- PMC10550791
- NLM abbreviation
- Genes Brain Behav
- ISSN
- 1601-1848
- eISSN
- 1601-183X
- Grant note
- DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: U10AA008401
- Language
- English
- Electronic publication date
- 08/17/2023
- Date published
- 10/2023
- Academic Unit
- Psychiatry
- Record Identifier
- 9984456077602771
Metrics
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